Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice

IF 3.8 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Koki Sugimoto , Ayano Kosaka , Ryota Hosomi , Saki Itonori , Munehiro Yoshida , Kenji Fukunaga
{"title":"Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice","authors":"Koki Sugimoto ,&nbsp;Ayano Kosaka ,&nbsp;Ryota Hosomi ,&nbsp;Saki Itonori ,&nbsp;Munehiro Yoshida ,&nbsp;Kenji Fukunaga","doi":"10.1016/j.jff.2024.106569","DOIUrl":null,"url":null,"abstract":"<div><div>We discovered that the phospholipids present in the internal organs of scallops (<em>Patinopecten yessoensis</em>), which are primarily composed of glycerophospholipids and ceramide 2-aminoethylphosphonate (CAEP), reduced the serum and liver cholesterol contents in mice. This study evaluated the effects of scallop CAEP on lipid metabolism by comparing it to sphingomyelin. The study involved feeding four-week-old male KK-<em>A<sup>y</sup></em> mice either a high-fat diet or a high-fat diet supplemented with 0.5 wt% each of CAEP and sphingomyelin for 35 days. We found that CAEP intake lowered the serum triacylglycerol content, partly via a reduction in the mRNA expression levels of fatty acid synthesis-related genes in the liver. Furthermore, the CAEP diet reduced the serum and liver cholesterol contents. This effect was partially mediated by the increase in fecal total sterol excretion. Thus, this study indicates CAEP will be employed as a health-promoting component to lower the body’s triacylglycerol and cholesterol contents.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106569"},"PeriodicalIF":3.8000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464624005723","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

We discovered that the phospholipids present in the internal organs of scallops (Patinopecten yessoensis), which are primarily composed of glycerophospholipids and ceramide 2-aminoethylphosphonate (CAEP), reduced the serum and liver cholesterol contents in mice. This study evaluated the effects of scallop CAEP on lipid metabolism by comparing it to sphingomyelin. The study involved feeding four-week-old male KK-Ay mice either a high-fat diet or a high-fat diet supplemented with 0.5 wt% each of CAEP and sphingomyelin for 35 days. We found that CAEP intake lowered the serum triacylglycerol content, partly via a reduction in the mRNA expression levels of fatty acid synthesis-related genes in the liver. Furthermore, the CAEP diet reduced the serum and liver cholesterol contents. This effect was partially mediated by the increase in fecal total sterol excretion. Thus, this study indicates CAEP will be employed as a health-promoting component to lower the body’s triacylglycerol and cholesterol contents.

Abstract Image

在改善肥胖/Ⅱ型糖尿病 KK-Ay 小鼠胆固醇代谢方面,扇贝神经酰胺 2-氨基乙基膦酸盐比蛋黄鞘磷脂更有效
我们发现,扇贝(Patinopecten yessoensis)内脏中的磷脂(主要由甘油磷脂和 2-氨基乙基膦酸神经酰胺(CAEP)组成)能降低小鼠血清和肝脏中的胆固醇含量。本研究通过将扇贝 CAEP 与鞘磷脂进行比较,评估了扇贝 CAEP 对脂质代谢的影响。研究采用高脂肪饮食或高脂肪饮食(CAEP 和鞘磷脂各占 0.5 wt%)喂养 4 周大的雄性 KK-Ay 小鼠,连续喂养 35 天。我们发现,摄入 CAEP 可降低血清中的三酰甘油含量,部分原因是肝脏中脂肪酸合成相关基因的 mRNA 表达水平降低。此外,CAEP 还降低了血清和肝脏中胆固醇的含量。这种效应部分是通过粪便总固醇排泄量的增加而产生的。因此,这项研究表明,CAEP 可作为一种促进健康的成分,用于降低人体的三酰甘油和胆固醇含量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Functional Foods
Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-
CiteScore
9.60
自引率
1.80%
发文量
428
审稿时长
76 days
期刊介绍: Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信