Maternal odd-chain fatty acid-rich algal oil supplementation during pregnancy improves litter characteristics of intrauterine growth restricted pregnant mice via regulating placental function

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2024-11-21 DOI:10.1016/j.jff.2024.106586

Yi Li , Yujun Wu , Meng Liu , Dandan Han , Yanwei Xu , Bingxu Huang , Fang Cong , Mengmeng Li , Bo Cao , Cuiping Feng , Hongbiao Ding , Junjun Wang

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Abstract

Intrauterine growth restriction (IUGR) severely impairs fetal development and offspring health. Odd-chain fatty acid (OCFA) possess beneficial biological activities in regulating insulin resistance, inflammation and oxidative stress. However, the effects of OCFA on improving IUGR through regulating placental function and maternal health remain unclear. Herein, maternal OCFA-rich algal oil supplementation improved variable coefficient of fetal weight and fetal oxidative stress in low protein diet (LPD)-induced IUGR mice model. OCFA-rich algal oil also improved placental dysfunction, placental fatty acid metabolism disorder, maternal insulin resistance, oxidative stress and intestinal injury, suggesting an improved maternal health. OCFA-rich algal oil reshaped the intestinal microbiome of dams, decreasing unclassified Bacteroidales and Parvibacter, and increasing Weissella, which positively impacted insulin resistance and intestinal injury. Overall, OCFA-rich algal oil supplementation during pregnancy ameliorated oxidative stress, insulin resistance and intestinal injury in LPD-induced IUGR pregnant mice, improved placental functions and litter characteristics, and further enhanced fetal antioxidant capacity.

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孕期补充富含奇链脂肪酸的母体海藻油，可通过调节胎盘功能改善宫内生长受限妊娠小鼠的胎仔特征

宫内生长受限（IUGR）严重影响胎儿发育和后代健康。奇链脂肪酸（OCFA）在调节胰岛素抵抗、炎症和氧化应激方面具有有益的生物活性。然而，奇链脂肪酸通过调节胎盘功能和母体健康来改善 IUGR 的效果仍不清楚。在本文中，母体补充富含 OCFA 的海藻油能改善低蛋白饮食（LPD）诱导的 IUGR 小鼠模型中胎儿体重和胎儿氧化应激的可变系数。富含 OCFA 的海藻油还能改善胎盘功能障碍、胎盘脂肪酸代谢紊乱、母体胰岛素抵抗、氧化应激和肠道损伤，从而改善母体健康。富含 OCFA 的海藻油重塑了母体的肠道微生物群，减少了未分类的类杆菌和副杆菌，增加了魏氏菌，从而对胰岛素抵抗和肠道损伤产生了积极影响。总之，孕期补充富含 OCFA 的海藻油能改善 LPD 诱导的 IUGR 怀孕小鼠的氧化应激、胰岛素抵抗和肠道损伤，改善胎盘功能和胎仔特征，并进一步提高胎儿的抗氧化能力。

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.