Martin Lück, Stefan Klinken-Uth, Peter Kleinebudde
{"title":"Kinetics of elastic recovery in roll compaction","authors":"Martin Lück, Stefan Klinken-Uth, Peter Kleinebudde","doi":"10.1016/j.ijpx.2024.100303","DOIUrl":null,"url":null,"abstract":"<div><div>Elastic recovery (<span><math><mi>ER</mi></math></span>) has been investigated and discussed extensively in the field of tableting. However, until now only limited data is available regarding <span><math><mi>ER</mi></math></span> in roll compaction. Therefore, a previously established in-line measurement technique was rolled out to further investigate the kinetics of <span><math><mi>ER</mi></math></span> in roll compaction and the effects of specific compaction force (<span><math><mi>SCF</mi></math></span>) and roll speed (<span><math><mi>RS</mi></math></span>). In-line laser triangulation measurements at different positions within a roll rotation as well as measurement over time after the process has been stopped were utilized. Pure microcrystalline cellulose (<span><math><mi>MCC</mi></math></span>) and two placebo powder blend formulations were analysed. Successful fit of the contained <span><math><mi>ER</mi></math></span> profiles emphasized that the <span><math><mi>ER</mi></math></span> on the roll surface is build out of two exponential kinetics. Starting with a dominating fast <span><math><mi>ER</mi></math></span> (<span><math><msub><mi>ER</mi><mi>A</mi></msub></math></span>), characterized by a high increase of the ribbon thickness after passing the gap width, followed by a slower <span><math><mi>ER</mi></math></span> (<span><math><msub><mi>ER</mi><mi>B</mi></msub></math></span>). Sigma minus plot analysis showed that increasing <span><math><mi>RS</mi></math></span> led to an accelerated <span><math><msub><mi>ER</mi><mi>A</mi></msub></math></span> and <span><math><msub><mi>ER</mi><mi>B</mi></msub></math></span> which was related to the viscoelastic behaviour of <span><math><mi>MCC</mi></math></span>. The <span><math><mi>SCF</mi></math></span> only had an effect on the kinetics of <span><math><mi>ER</mi></math></span> if a brittle filler was added to the mixture. The conducted study established the first approach in literature to characterize the kinetics of <span><math><mi>ER</mi></math></span> in roll compaction. It supports the understanding and characterization of relaxation times and the effect of the <span><math><mi>RS</mi></math></span> and <span><math><mi>SCF</mi></math></span> in roll compaction.</div></div>","PeriodicalId":14280,"journal":{"name":"International Journal of Pharmaceutics: X","volume":"8 ","pages":"Article 100303"},"PeriodicalIF":5.2000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutics: X","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590156724000756","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Elastic recovery () has been investigated and discussed extensively in the field of tableting. However, until now only limited data is available regarding in roll compaction. Therefore, a previously established in-line measurement technique was rolled out to further investigate the kinetics of in roll compaction and the effects of specific compaction force () and roll speed (). In-line laser triangulation measurements at different positions within a roll rotation as well as measurement over time after the process has been stopped were utilized. Pure microcrystalline cellulose () and two placebo powder blend formulations were analysed. Successful fit of the contained profiles emphasized that the on the roll surface is build out of two exponential kinetics. Starting with a dominating fast (), characterized by a high increase of the ribbon thickness after passing the gap width, followed by a slower (). Sigma minus plot analysis showed that increasing led to an accelerated and which was related to the viscoelastic behaviour of . The only had an effect on the kinetics of if a brittle filler was added to the mixture. The conducted study established the first approach in literature to characterize the kinetics of in roll compaction. It supports the understanding and characterization of relaxation times and the effect of the and in roll compaction.
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