Disease characteristics of NMOSD and their relationship with disease burden: Observations from a large single-center cohort

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Journal of the Neurological Sciences Pub Date : 2024-11-16 DOI:10.1016/j.jns.2024.123311

Suban Amatya MBBS , Erum Khan MD , Yusuf Kagzi MD , Sema Akkus MBBS , Rajesh Gupta MD , Nicholas Hansen MS , Sijin Wen PhD , Shruti Jaiswal MS , Shitiz Sriwastava MD

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引用次数: 0

Abstract

Objective

To assess the demographic, clinical, and outcome data in patients with NMOSD across a single-center adult cohort and find out associations, if any, with the disease burden.

Background

Neuromyelitis Optica spectrum disorder is an autoimmune condition with unpredictable course and relapses. The clinical and economic burden of NMOSD has been studied less.

Design/methods

A retrospective analysis of patients diagnosed with NMOSD according to 2015 criteria at the UT Health Houston (UTH) system from 2010 to 2024 was done.

Results

Of the 68 patients, aged 40.03 yrs. (SD = 14.05), 56 (82.35 %) were females, and 17 (25.75 %) had a median household income below 2 times the poverty threshold. 51 (76.11 %) had positive aquaporin4 antibodies, 39 had optic neuritis (57.35 %), and 29 (42.63 %) had myelitis. We classified total relapses into less than 3 vs more than 3, cumulative days of hospitalization into less than 5 vs more than 5, and readmission frequency as less than 1 vs more than 1 per year.

The majority of cases had less than 3 relapses (S_N = 38 vs 11, M_N = 22 vs 6, p > .05), less than 5 days of cumulative hospitalizations (S_N = 29 vs 6, M_N = 15 vs 5, p > .05), and less than 1 readmissions in a year (S_N 15 vs 5, p > .05, M_N = 14 vs 10, p > .05).

Conclusion

The severity of the disease can be attributed to the major clinical criteria at the time of diagnosis. This can be helpful to identify cases that may have a higher disease burden to the patient and the hospital. Larger studies are needed to confirm the same.

查看原文本刊更多论文

NMOSD 的疾病特征及其与疾病负担的关系：来自大型单中心队列的观察结果

背景神经脊髓炎谱系障碍是一种自身免疫性疾病，病程和复发难以预测。结果在68名年龄为40.03岁（SD=14.05）的患者中，56人（82.35%）为女性，17人（25.75%）的家庭收入中位数低于贫困线的2倍。51人（76.11%）的水光蛋白4抗体呈阳性，39人（57.35%）患有视神经炎，29人（42.63%）患有脊髓炎。我们将总复发次数分为少于 3 次与多于 3 次，累计住院天数分为少于 5 天与多于 5 天，每年再入院次数分为少于 1 次与多于 1 次。大多数病例的复发次数少于 3 次（SN = 38 vs 11，MN = 22 vs 6，p > .05），累计住院天数少于 5 天（SN = 29 vs 6，MN = 15 vs 5，p > .05），一年内再入院次数少于 1 次（SN = 15 vs 5，p > .05，MN = 14 vs 10，p > .05）。这有助于确定对患者和医院造成较大疾病负担的病例。需要更大规模的研究来证实这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Neurological Sciences 医学-临床神经学

CiteScore

7.60

自引率

2.30%

发文量

313

审稿时长

22 days

期刊介绍： The Journal of the Neurological Sciences provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. JNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). JNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism.