Influence of manufacturing parameters on bioactive glass 45S5: Structural analysis and applications in bone tissue engineering

IF 5.1 2区 材料科学 Q1 MATERIALS SCIENCE, CERAMICS
K.W. Santos , K.J.S.G. Costa , I.S. Gonçalves , M. Alves , D.P. Lauda , L.M.R. Vasconcellos , T.M.B. Campos , I.R. Oliveira
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Abstract

Bioactive glass (BG-45S5) production through the melting process is affected by a wide variety of parameters. This study investigated the synthesis of BG-45S5 granules and the process variables to produce a bioactive and osteoinductive BG for bone grafting applications. The melting process was initially analyzed by varying parameters such as crucible type and pouring environment using P2O5 as phosphorus precursor. The obtained products were characterized by crystalline phases, characteristic chemical groups, particle size distribution, and chemical composition. Materials poured into graphite or steel molds resulted in particle sizes more suitable for applications in granular form. Using a platinum crucible yielded a chemical composition closer to the target when compared with another ceramic crucible. Subsequently, the melting process was evaluated to different phosphorus precursor (P2O5 or Na2HPO4) and melting duration (1 or 2 h) in a platinum crucible verifying their effects on the thermal behavior, chemical composition and structure of BG-45S5. Employing Na2HPO4 as a precursor led to higher glass transition and crystallization temperatures as compared to P2O5, enhancing glass homogeneity and structural stability. The product with better characteristics in terms of composition and structure was further characterized for bioactivity and cell culture behavior, showing a greater amount of mineralization nodules when compared to commercial hydroxyapatite. This is particularly due to its behavior as the solubility and interaction in biological environments.
制造参数对生物活性玻璃 45S5:结构分析及在骨组织工程中的应用的影响
通过熔化工艺生产生物活性玻璃(BG-45S5)受到多种参数的影响。本研究调查了 BG-45S5 颗粒的合成和工艺变量,以生产出具有生物活性和骨诱导性的 BG,用于骨移植应用。以 P2O5 为磷前体,通过改变坩埚类型和浇注环境等参数对熔化过程进行了初步分析。所得产品的特征包括结晶相、特征化学基团、粒度分布和化学成分。浇注到石墨或钢模中的材料的粒度更适合颗粒状应用。与另一种陶瓷坩埚相比,使用铂金坩埚得到的化学成分更接近目标值。随后,对铂坩埚中不同磷前驱体(P2O5 或 Na2HPO4)和熔化时间(1 或 2 小时)的熔化过程进行了评估,验证了它们对 BG-45S5 的热行为、化学成分和结构的影响。与 P2O5 相比,使用 Na2HPO4 作为前驱体可提高玻璃化转变温度和结晶温度,从而增强玻璃均匀性和结构稳定性。与商业羟基磷灰石相比,具有更好成分和结构特性的产品显示出更多的矿化结节。这主要是由于其在生物环境中的溶解性和相互作用行为。
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来源期刊
Ceramics International
Ceramics International 工程技术-材料科学:硅酸盐
CiteScore
9.40
自引率
15.40%
发文量
4558
审稿时长
25 days
期刊介绍: Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties. Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour. Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.
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