Sr-Mg co-doped Hardystonite/Polycaprolactone electrospun scaffolds: Fabrication and characterization for enhanced bone regeneration

IF 5.1 2区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Ceramics International Pub Date : 2024-10-02 DOI:10.1016/j.ceramint.2024.10.012

Pegah Dehghanpour, Rahmatollah Emadi, Hamidreza Salimijazi

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Abstract

The production of scaffolds is a primary objective in tissue engineering for treating bone defects and diseases. The electrospinning process offers a promising technique to create structures resembling the extracellular matrix. Artificial polymeric grafts, such as poly(caprolactone) (PCL), often face issues of low strength and degradation. To overcome these limitations, we introduce ceramic reinforcing particles, specifically hardystonite (Ca₂ZnSi₂O₇), known for its benefits in tissue regeneration. Considering the undeniable role of strontium and magnesium in bone regeneration, the aim of this study was to investigate and compare produced scaffolds with and without dopant elements, incorporated into hardystonite. Initially, strontium-magnesium-doped hardystonite (DHT) nanopowder was synthesized through mechanical milling followed by thermal treatment. The successful formation of a single-phase hardystonite structure was verified by X-ray diffraction (XRD), with estimated crystallite and particle sizes of approximately 41.6 nm and 77.23 ± 36.60 nm, respectively. Subsequently, PCL/DHT composite scaffolds were fabricated with 3 wt%, 5 wt%, and 10 wt% bioceramic content. These scaffolds were assessed for fiber morphology, physical and chemical properties, hydrophilicity, surface roughness, mechanical characteristics, degradation, and biocompatibility. The results indicate that PCL/5 wt% DHT scaffolds exhibit superior biological, physical, and mechanical properties. Across all these tests, the PCL/5 wt% DHT scaffold consistently outperformed the others, suggesting its promising potential in bone tissue engineering.

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锶镁共掺杂的哈氏石/聚己内酯电纺支架：用于增强骨再生的制造和表征

生产支架是组织工程学治疗骨骼缺损和疾病的主要目标。电纺丝工艺为制造类似细胞外基质的结构提供了一种前景广阔的技术。聚（己内酯）（PCL）等人工聚合物移植物通常面临强度低和降解的问题。为了克服这些局限性，我们引入了陶瓷增强颗粒，特别是硬石膏（Ca2ZnSi2O7），它在组织再生方面的优势众所周知。考虑到锶和镁在骨再生中不可否认的作用，本研究旨在调查和比较在硬石膏中加入和不加入掺杂元素的支架。首先，通过机械研磨合成了掺锶掺镁的硬石膏（DHT）纳米粉体，然后进行了热处理。X 射线衍射（XRD）验证了单相硬石膏结构的成功形成，估计结晶和颗粒尺寸分别约为 41.6 nm 和 77.23 ± 36.60 nm。随后，制作了生物陶瓷含量分别为 3 wt%、5 wt% 和 10 wt% 的 PCL/DHT 复合支架。对这些支架的纤维形态、物理和化学特性、亲水性、表面粗糙度、机械特性、降解性和生物相容性进行了评估。结果表明，PCL/5 wt% DHT 支架具有优异的生物、物理和机械性能。在所有这些测试中，PCL/5 wt% DHT 支架的性能始终优于其他支架，这表明它在骨组织工程中具有广阔的应用前景。

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来源期刊

Ceramics International 工程技术-材料科学：硅酸盐

CiteScore

9.40

自引率

15.40%

发文量

4558

审稿时长

25 days

期刊介绍： Ceramics International covers the science of advanced ceramic materials. The journal encourages contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain materials with desired structural features and properties. Ceramics International covers oxide and non-oxide ceramics, functional glasses, glass ceramics, amorphous inorganic non-metallic materials (and their combinations with metal and organic materials), in the form of particulates, dense or porous bodies, thin/thick films and laminated, graded and composite structures. Process related topics such as ceramic-ceramic joints or joining ceramics with dissimilar materials, as well as surface finishing and conditioning are also covered. Besides traditional processing techniques, manufacturing routes of interest include innovative procedures benefiting from externally applied stresses, electromagnetic fields and energetic beams, as well as top-down and self-assembly nanotechnology approaches. In addition, the journal welcomes submissions on bio-inspired and bio-enabled materials designs, experimentally validated multi scale modelling and simulation for materials design, and the use of the most advanced chemical and physical characterization techniques of structure, properties and behaviour. Technologically relevant low-dimensional systems are a particular focus of Ceramics International. These include 0, 1 and 2-D nanomaterials (also covering CNTs, graphene and related materials, and diamond-like carbons), their nanocomposites, as well as nano-hybrids and hierarchical multifunctional nanostructures that might integrate molecular, biological and electronic components.