Botulinum toxin type a (BOTOX) in the management of glossopharyngeal neuralgia- A case series

Q3 Medicine

Operative Techniques in Otolaryngology - Head and Neck Surgery Pub Date : 2024-09-01 DOI:10.1016/j.otot.2024.08.002

Prashanth Lowell Monis MDS, Athiramol CK MDS, Samarth Shetty MDS, MFDS RCS (Eng.), FFDRCS (Ire.), Paul Christadas Salins MDS, FDS RCS (Eng.), FFDRCS (Ire.), PG Dip. Med

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引用次数: 0

Abstract

Glossopharyngeal neuralgia (GPN) is a rare, debilitating neurologic condition characterized by intermittent pain radiating to the tongue, pharynx or ear that can be triggered by talking, swallowing or chewing. With an incidence of only 0.2-0.7 persons/100,000/year, the diagnosis is extremely challenging and often gets misdiagnosed and undiagnosed. Many treatment options have been tried by various clinicians in the past, such as medical therapy (antidepressants, opiods, antiepileptics, steroids, and membrane-stabilizing agents), nerve blocks with or without additives, gamma knife radiosurgery, radiofrequency ablation and microvascular decompression. Each of the aforementioned treatment modalities has its own merits and limitations. In the pursuit of delivering optimal treatment for pain relief in GPN and to improve patient's quality of life, we have explored the use of Botulinum toxin type A (BOTOX [Allegran]). BOTOX has been widely used in the treatment of chronic facial pain such as headaches, migraine, and trigeminal neuralgia. However, the use of BOTOX in the management of GPN has not been reported in the literature. Despite the small number of cases in our series, BOTOX therapy in GPN appears to be promising. However, further research with larger sample sizes and longer follow-up periods is needed to fully establish its efficacy and safety profile

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A 型肉毒杆菌毒素（BOTOX）治疗舌咽神经痛--病例系列

舌咽神经痛（GPN）是一种罕见的、使人衰弱的神经系统疾病，其特征是间歇性疼痛，放射至舌头、咽部或耳朵，可由说话、吞咽或咀嚼引发。该病的发病率仅为 0.2-0.7 人/10 万/年，诊断极具挑战性，经常被误诊或漏诊。过去，不同的临床医生尝试过许多治疗方案，如药物治疗（抗抑郁药、鸦片类药物、抗癫痫药、类固醇和膜稳定剂）、使用或不使用添加剂的神经阻滞、伽马刀放射外科手术、射频消融术和微血管减压术。上述每种治疗方法都有其优点和局限性。为了达到最佳的治疗效果，缓解 GPN 患者的疼痛，提高患者的生活质量，我们探索使用 A 型肉毒杆菌毒素（BOTOX [Allegran]）。BOTOX 已被广泛用于治疗慢性面部疼痛，如头痛、偏头痛和三叉神经痛。然而，将 BOTOX 用于治疗 GPN 的文献尚未见报道。尽管在我们的系列研究中，BOTOX 治疗 GPN 的病例数量较少，但似乎很有前景。不过，还需要进行样本量更大、随访时间更长的进一步研究，以充分确定其疗效和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Operative Techniques in Otolaryngology - Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.70

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： This large-size, atlas-format journal presents detailed illustrations of new surgical procedures and techniques in otology, rhinology, laryngology, reconstructive head and neck surgery, and facial plastic surgery. Feature articles in each issue are related to a central theme by anatomic area or disease process. The journal will also often contain articles on complications, diagnosis, treatment or rehabilitation. New techniques that are non-operative are also featured.