Recent advances in the biosynthesis and production optimization of gentamicin: A critical review

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Synthetic and Systems Biotechnology Pub Date : 2024-11-14 DOI:10.1016/j.synbio.2024.11.003

Feng Xu, Kaihao Hu, Ali Mohsin, Jie Wu, Lihuan Su, Yuan Wang, Rong Ben, Hao Gao, Xiwei Tian, Ju Chu

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Abstract

Gentamicin, an aminoglycoside antibiotic, is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases. Comprising a complex array of closely related aminoglycoside compounds, the gentamicin B and C complexes emerge as particularly pertinent in clinical contexts. This review outlines the latest advancements in the biosynthesis and production of gentamicin, commencing with a comprehensive overview of its biosynthetic pathway. Subsequently, the article encapsulates a spectrum of strategies currently deployed to augment gentamicin yields. These strategies include mutation screening, molecular biological techniques, and optimization of the fermentation process. Moreover, numerous methods have been documented for detecting gentamicin across a range of matrices, underscoring the significance of precise quantitative analysis. Finally, the review furnishes an exhaustive market analysis and future outlook, elucidating prevailing trends and challenges within the gentamicin industry. Overall, this article serves as a pivotal resource for researchers and professionals engaged in gentamicin research, furnishing a meticulous introduction to efficient synthesis technologies and diverse applications, alongside presenting innovative concepts and methodologies aimed at increasing gentamicin production.

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庆大霉素生物合成和生产优化的最新进展：重要综述

庆大霉素是一种氨基糖苷类抗生素，由小单胞菌属中的少数几个物种产生，因其在抗击多种传染病方面的广谱疗效而备受关注。庆大霉素 B 和 C 复合物由一系列密切相关的氨基糖苷化合物组成，在临床上尤为重要。本综述概述了庆大霉素生物合成和生产方面的最新进展，首先对其生物合成途径进行了全面概述。随后，文章概述了目前为提高庆大霉素产量而采取的一系列策略。这些策略包括突变筛选、分子生物学技术和发酵过程优化。此外，文章还介绍了在各种基质中检测庆大霉素的多种方法，强调了精确定量分析的重要性。最后，综述提供了详尽的市场分析和未来展望，阐明了庆大霉素行业的当前趋势和挑战。总之，这篇文章为从事庆大霉素研究的研究人员和专业人士提供了重要的资源，细致地介绍了高效合成技术和各种应用，同时提出了旨在提高庆大霉素产量的创新概念和方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic and Systems Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

6.90

自引率

12.50%

发文量

审稿时长

67 days

期刊介绍： Synthetic and Systems Biotechnology aims to promote the communication of original research in synthetic and systems biology, with strong emphasis on applications towards biotechnology. This journal is a quarterly peer-reviewed journal led by Editor-in-Chief Lixin Zhang. The journal publishes high-quality research; focusing on integrative approaches to enable the understanding and design of biological systems, and research to develop the application of systems and synthetic biology to natural systems. This journal will publish Articles, Short notes, Methods, Mini Reviews, Commentary and Conference reviews.