Candida antarctica lipase B catalyzed condensation reactions: Water mediated chemo-enzymatic synthesis of different heterocycles

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2024-11-17 DOI:10.1016/j.tetlet.2024.155371

Satyaveni Malasala , Anusha Polomani , Jitendra Gour , Srinivas Nanduri

引用次数: 0

Abstract

A water-mediated, chemoenzymatic reaction has been developed for synthesizing various heterocycles. This reported method is compatible with various condensation reactions and multi-component reactions, such as the Biginelli reaction. It offers direct access to benzothiazole, benzimidazole, benzoxazole, quinazolinone, and pyrimidines using straightforward reaction conditions, adhering to green chemistry principles.

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白色念珠菌脂肪酶 B 催化的缩合反应：水介导的不同杂环的化学酶法合成

我们开发了一种以水为介质的化学酶促反应，用于合成各种杂环。所报道的这种方法与各种缩合反应和多组分反应（如 Biginelli 反应）兼容。它采用简单的反应条件，遵循绿色化学原则，可直接获得苯并噻唑、苯并咪唑、苯并恶唑、喹唑啉酮和嘧啶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.