Associations between breast radiation dermatitis and post-mastectomy pain syndrome in patients with breast cancer: A multicenter retrospective study

Abstract

Objective

This study explores the relationship between breast radiation dermatitis (BRD) and post-mastectomy pain syndrome (PMPS) among patients with breast cancer. Both BRD and PMPS significantly impact quality of life, yet their correlation and risk factors require further investigation.

Methods

We conducted a multicenter retrospective analysis of 784 patients with breast cancer who underwent postoperative radiotherapy between 2017 and 2023. Clinical data on BRD and PMPS were collected through patient questionnaires and hospital records, examining risk factors and evaluating the prevalence of PMPS among those with BRD.

Results

BRD affected 81.25% of patients, with higher incidence among older and obese individuals. PMPS was observed in 23.4% of the BRD group versus 13.6% in non-BRD patients (P=0.009). Early BRD onset during radiotherapy (P=0.004) and larger dermatitis areas (P=0.000) were strongly associated with increased PMPS risk.

Conclusions

This study highlights the significant relationship between BRD and PMPS, underscoring the need for early interventions to manage BRD and reduce chronic pain risk. Tailored care strategies could improve outcomes for high-risk patients.