Ultrasound-assisted aberration correction of transcranial photoacoustic imaging based on angular spectrum theory

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2024-11-09 DOI:10.1016/j.pacs.2024.100665

Qiuqin Mao, Yingjie Feng, Chao Tao, Xiaojun Liu

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Abstract

To correct the refraction aberration induced by the skull in photoacoustic imaging, a method for phase distortion compensation is proposed based on the angular spectrum theory with the aid of ultrasonic signals. This method first updates the speed of sound distribution by iteratively performing aberration correction in the ultrasonic reconstruction. Then the speed of sound distribution obtained with ultrasound-assisted serves as prior knowledge to address phase distortion compensation by adjusting the phase shift factor of the wavefront in different media. Finally, the aberration-corrected ultrasonic-photoacoustic dual-modality image can be obtained. Numerical simulations and phantom experiments confirm the effectiveness of this method. Specifically, in simulations, the position error of the proposed method is reduced from −13.61 % to 1.27 % in depth compared to the method based on the reconstruction with constant speed. Moreover, a real ex-vivo rabbit skull experiment illustrates the potential biological application of the proposed method in transcranial photoacoustic imaging.

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基于角频谱理论的经颅光声成像超声辅助像差校正技术

为了校正光声成像中头骨引起的折射像差，提出了一种基于角频谱理论并借助超声波信号进行相位畸变补偿的方法。该方法首先通过在超声波重建中迭代执行像差校正来更新声速分布。然后，将超声波辅助获得的声速分布作为先验知识，通过调整不同介质中波面的相移因子来解决相位失真补偿问题。最后，就能获得畸变校正后的超声-光声双模态图像。数值模拟和模型实验证实了这种方法的有效性。具体来说，在模拟中，与基于恒速重建的方法相比，所建议方法的深度位置误差从-13.61%降至1.27%。此外，一个真实的活体兔头骨实验说明了所提方法在经颅光声成像中的潜在生物应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.