Prevalence of mixed neuropathologies in age-related neurodegenerative diseases: A community-based autopsy study in China

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-11-25 DOI:10.1002/alz.14369

Xiaoxi Wang, Keqing Zhu, Wei Wu, Dan Zhou, Hui Lu, Juan Du, Li Cai, Xiaoxin Yan, Wensheng Li, Xiaojing Qian, Xue Wang, Chao Ma, Yuting Hu, Chen Tian, Bing Sun, Zheng Fang, Juanli Wu, Peiran Jiang, Jianxin Liu, Cuiyun Liu, Jiayao Fan, Huixian Cui, Yi Shen, Shumin Duan, Aimin Bao, Ying Yang, Wenying Qiu, Jing Zhang

{"title":"Prevalence of mixed neuropathologies in age-related neurodegenerative diseases: A community-based autopsy study in China","authors":"Xiaoxi Wang, Keqing Zhu, Wei Wu, Dan Zhou, Hui Lu, Juan Du, Li Cai, Xiaoxin Yan, Wensheng Li, Xiaojing Qian, Xue Wang, Chao Ma, Yuting Hu, Chen Tian, Bing Sun, Zheng Fang, Juanli Wu, Peiran Jiang, Jianxin Liu, Cuiyun Liu, Jiayao Fan, Huixian Cui, Yi Shen, Shumin Duan, Aimin Bao, Ying Yang, Wenying Qiu, Jing Zhang","doi":"10.1002/alz.14369","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples from Chinese brain banks.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>A total of 1142 brains from six Chinese brain banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations of neurological disorders were analyzed.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Significant proportions of brains displayed primary age-related tauopathy (PART, 35%), limbic-predominant age-related TDP-43 encephalopathy (LATE, 46%), and aging-related tau astrogliopathy (ARTAG, 12%). Alzheimer's disease neuropathological change (ADNC, 48%), Lewy body disease (LBD, 13%), and cerebrovascular disease (CVD, 63%) were also prevalent, often co-occurring with regional variations. CVD emerged as the potential most early contributor to neuropathological changes.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>This analysis highlights the prevalence of PART, LATE, ARTAG, ADNC, LBD, and CVD, with regional differences. The findings suggest CVD may be the earliest contributing factor, potentially preceding other neuropathologies.</p>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>The prevalence of primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), aging-related tau astrogliopathy (ARTAG), Alzheimer's disease neuropathologic change, Lewy body disease, and cerebrovascular disease (CVD) in China, increasing with age, is comparable to other countries.</li>\n \n <li>Significant regional differences in the prevalences of diseases are noted.</li>\n \n <li>CVD develops prior to any other disorders, including PART, LATE, and ARTAG.</li>\n </ul>\n </div>\n </section>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14369","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.14369","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples from Chinese brain banks.

METHODS

A total of 1142 brains from six Chinese brain banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations of neurological disorders were analyzed.

RESULTS

Significant proportions of brains displayed primary age-related tauopathy (PART, 35%), limbic-predominant age-related TDP-43 encephalopathy (LATE, 46%), and aging-related tau astrogliopathy (ARTAG, 12%). Alzheimer's disease neuropathological change (ADNC, 48%), Lewy body disease (LBD, 13%), and cerebrovascular disease (CVD, 63%) were also prevalent, often co-occurring with regional variations. CVD emerged as the potential most early contributor to neuropathological changes.

DISCUSSION

This analysis highlights the prevalence of PART, LATE, ARTAG, ADNC, LBD, and CVD, with regional differences. The findings suggest CVD may be the earliest contributing factor, potentially preceding other neuropathologies.

Highlights

The prevalence of primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), aging-related tau astrogliopathy (ARTAG), Alzheimer's disease neuropathologic change, Lewy body disease, and cerebrovascular disease (CVD) in China, increasing with age, is comparable to other countries.
Significant regional differences in the prevalences of diseases are noted.
CVD develops prior to any other disorders, including PART, LATE, and ARTAG.

Abstract Image

查看原文本刊更多论文

与年龄相关的神经退行性疾病中混合神经病理学的流行：中国基于社区的尸检研究

尽管有关混合神经病理的研究非常广泛，但来自中国的数据却非常有限。本研究旨在通过分析来自中国脑库的脑样本来填补这一空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.