Customizable patterned membranes for cardiac tissue engineering: A model-assisted design method

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-11-19 DOI:10.1016/j.jmbbm.2024.106815

Bertrand Guibert , Aurelia Poerio , Lisa Nicole , Julia Budzinski , Mélanie M. Leroux , Solenne Fleutot , Marc Ponçot , Franck Cleymand , Thierry Bastogne , Jean-Philippe Jehl

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引用次数: 0

Abstract

Myocardial infarction can cause irreversible damage to the heart muscle, which can lead to heart failure. The difficulty of the treatment mainly arises from the anisotropic behavior of the myocardium fibrous structure. Patches or cardiac restraint devices appear to be a promising approach to post-infarction treatment. In this study, we propose a new model-assisted method to design patterned membranes. The proposed approach combines computer experiments and statistical models to optimize the design parameters and to meet the requirement for the post-infarction treatment. Finite element model, global sensitivity analysis, random forest model and response surface model are the key components of the strategy implemented in this study, which is applied to design a real membrane. The metamodel-based design method is able to estimate the equivalent Young’s modulus of the membrane in a few seconds and optimization results have been validated a posteriori by laboratory measurements. This solution opens up new prospects for the design of customized membranes with technical specifications tailored to each patient.

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用于心脏组织工程的可定制图案膜：模型辅助设计法

心肌梗死会对心肌造成不可逆的损伤，从而导致心力衰竭。治疗的困难主要在于心肌纤维结构的各向异性。贴片或心脏束缚装置似乎是一种很有前景的梗死后治疗方法。在本研究中，我们提出了一种新的模型辅助方法来设计图案膜。该方法结合了计算机实验和统计模型来优化设计参数，以满足梗死后治疗的要求。有限元模型、全局敏感性分析、随机森林模型和响应面模型是本研究实施的策略的关键组成部分，并将其应用于实际膜的设计。基于元模型的设计方法能够在几秒钟内估算出膜的等效杨氏模量，并通过实验室测量对优化结果进行了后验。这一解决方案为设计符合每位患者技术规格的定制膜开辟了新的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.