The Value of Necrotic Area Features in Contrast-Enhanced Ultrasound for Distinguishing Between Benign and Malignant Subpleural Pulmonary Lesions

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-02-01 DOI:10.1016/j.ultrasmedbio.2024.11.008

Yang Cong, Jiawei Yi, Ke Bi, Yi Zhang, Mengjun Shen, HuiMing Zhu, Yin Wang

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Abstract

Objective

To analyze Necrotic Area Features of subpleural pulmonary lesions (SPLs) demonstrated by contrast-enhanced ultrasound (CEUS) and investigate their value in differentiating between malignant and benign SPLs.

Methods

Patients with SPLs who underwent CEUS at our hospital from January to May 2021. The following patient information was recorded: (i) age, (ii) sex, (iii) lesion size, (iv) lesion location, (v) size of necrotic areas and (vi) necrotic area morphology, including sieve-like necrosis, necrotic area with septal enhancement, necrotic area with annular enhancement margins, and necrotic area with burr-like enhancement margins. These parameters were analyzed using univariate and multivariate logistic regression. Subgroup analyses based on lesion size were further conducted using the collected data.

Results

A total of 212 patients with 212 SPLs were enrolled, comprising 99 benign and 113 malignant cases. Significant differences were observed between malignant and benign groups in terms of age, sex, lesion size and necrotic area morphology (all, p < 0.05).

Conclusion

Necrotic area's features observed on CEUS were valuable for distinguishing between benign and malignant SPLs. Age, sex, lesion size and the presence of burr-like enhancement margins are identified as independent predictors of malignant lesions.

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对比增强超声波中坏死区特征对区分良性和恶性胸膜下肺部病变的价值

目的分析对比增强超声（CEUS）显示的胸膜下肺部病变（SPLs）坏死区特征，并探讨其在区分恶性和良性SPLs中的价值：方法：2021 年 1 月至 5 月在我院接受 CEUS 检查的 SPL 患者。记录患者的以下信息：(i) 年龄；(ii) 性别；(iii) 病灶大小；(iv) 病灶位置；(v) 坏死区大小；(vi) 坏死区形态，包括筛状坏死、坏死区间隔增强、坏死区环状增强边缘、坏死区毛刺样增强边缘。采用单变量和多变量逻辑回归对这些参数进行了分析。根据收集到的数据进一步进行了基于病灶大小的亚组分析：共有 212 例 SPL 患者入选，其中良性病例 99 例，恶性病例 113 例。恶性组和良性组在年龄、性别、病灶大小和坏死区形态方面存在显著差异（均为 P <0.05）：结论：CEUS观察到的坏死区特征对区分良性和恶性SPL很有价值。年龄、性别、病变大小和毛刺样强化边缘的存在被认为是恶性病变的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.