The impact of insomnia on prefrontal activation during a verbal fluency task in patients with major depressive disorder: A preliminary fNIRS study

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY

Sleep medicine Pub Date : 2024-11-19 DOI:10.1016/j.sleep.2024.11.030

Shuai Yang , Xiaoyi Kong , Xiangxia Zhang , Yueming Zhang , Xueyan Li , Yi-Jun Ge

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引用次数: 0

Abstract

Background

Insomnia often co-occurs with major depressive disorder (MDD) and significantly affects patient recovery and prognosis. However, how insomnia affects prefrontal cortex activation in MDD patients and its association with both subjective and objective sleep quality remains unclear. This study combined functional near-infrared spectroscopy (fNIRS) with polysomnography (PSG) to investigate differences in prefrontal activation during a verbal fluency task (VFT) in patients with MDD, with and without insomnia.

Methods

Seventy-eight patients with MDD and 42 healthy controls underwent polysomnography and sleep and mood assessments including the Pittsburgh Sleep Quality Index (PSQI) and Self-Rating Depression Scale (SDS). Prefrontal activation was measured using fNIRS during the VFT.

Results

Patients with MDD and insomnia had higher PSQI scores than patients with MDD without insomnia. fNIRS revealed increased left prefrontal cortex activation in these patients, which was negatively correlated with the total sleep time and sleep efficiency and positively correlated with the PSQI score.

Conclusion

This study combined fNIRS and PSG to demonstrate that MDD patients with insomnia showed increased levels of prefrontal cortex activation, associated with both subjective and objective sleep quality.

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失眠对重度抑郁症患者在语言流畅性任务中前额叶激活的影响：一项初步的 fNIRS 研究。

背景：失眠经常与重度抑郁障碍（MDD）并发，并严重影响患者的康复和预后。然而，失眠如何影响 MDD 患者的前额叶皮层激活及其与主观和客观睡眠质量的关系仍不清楚。本研究将功能性近红外光谱（fNIRS）与多导睡眠图（PSG）相结合，研究了失眠和未失眠的 MDD 患者在语言流畅性任务（VFT）中前额叶激活的差异：78 名 MDD 患者和 42 名健康对照者接受了多导睡眠图检查和睡眠与情绪评估，包括匹兹堡睡眠质量指数 (PSQI) 和抑郁自评量表 (SDS)。在VFT过程中使用fNIRS测量了前额叶的激活情况：fNIRS显示这些患者左侧前额叶皮质激活增加，这与总睡眠时间和睡眠效率呈负相关，而与PSQI得分呈正相关：这项研究结合了 fNIRS 和 PSG，证明患有失眠症的 MDD 患者前额叶皮质激活水平升高，与主观和客观睡眠质量相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.