Choroidal thickness in the eyes of Parkinson's disease patients measured using optical coherence tomography: A systematic review and meta-analysis

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Journal of the Neurological Sciences Pub Date : 2024-11-12 DOI:10.1016/j.jns.2024.123294

Sepehr Fekrazad , Golnar Hassanzadeh , Zahra Esmaeili , Amirali Khosravi , Delia Cabrera DeBuc , Asadolah Movahedan

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引用次数: 0

Abstract

Background

Parkinson's disease (PD) presents a complex etiology involving genetics and environmental factors. Non-motor symptoms often precede motor manifestations. Dopaminergic neuron degeneration, oxidative stress, and vascular changes characterize PD. Retinal changes are studied as potential biomarkers, yet choroidal involvement remains unclear. This review aims to clarify choroidal thickness's role in PD progression for diagnostic advancements.

Methods

We examined PubMed, Scopus, and Embase databases. Depending on the heterogeneity, an appropriate model was used for the meta-analysis. Additionally, meta-regression, publication bias, subgroup analyses, and quality evaluation were carried out.

Results

We evaluated twelve studies involving 442 PD patients and 608 healthy controls. This study found insignificant differences in choroidal thickness between PD patients and healthy controls.

Conclusion

Choroidal thickness is influenced by age, axial length, and intraocular pressure, with PD potentially impacting thickness through neurodegenerative mechanisms. However, inconsistencies exist in the findings, warranting further investigation. Future studies should explore the impact of disease severity, medication effects, and other confounding variables on choroidal thickness in PD patients. Additionally, advanced imaging modalities like optical coherence tomography angiography (OCTA) may provide more comprehensive evaluations of choroidal vascular changes in PD.

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使用光学相干断层扫描测量帕金森病患者眼睛的脉络膜厚度：系统回顾与荟萃分析。

背景：帕金森病（PD）的病因复杂，涉及遗传和环境因素。非运动症状往往先于运动症状出现。多巴胺能神经元变性、氧化应激和血管变化是帕金森病的特征。视网膜变化被研究为潜在的生物标记物，但脉络膜受累情况仍不清楚。本综述旨在阐明脉络膜厚度在帕金森病进展过程中的作用，以促进诊断进展：我们研究了 PubMed、Scopus 和 Embase 数据库。根据异质性，我们采用了合适的模型进行荟萃分析。此外，我们还进行了荟萃回归、发表偏倚、亚组分析和质量评估：我们对涉及 442 名帕金森病患者和 608 名健康对照者的 12 项研究进行了评估。本研究发现，脉络膜厚度在帕金森病患者和健康对照组之间的差异并不明显：脉络膜厚度受年龄、轴向长度和眼压的影响，而帕金森病可能通过神经退行性机制影响脉络膜厚度。然而，研究结果存在不一致性，值得进一步研究。未来的研究应探讨疾病严重程度、药物作用和其他混杂变量对帕金森病患者脉络膜厚度的影响。此外，光学相干断层血管成像（OCTA）等先进的成像模式可对帕金森病脉络膜血管变化提供更全面的评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Neurological Sciences 医学-临床神经学

CiteScore

7.60

自引率

2.30%

发文量

313

审稿时长

22 days

期刊介绍： The Journal of the Neurological Sciences provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. JNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). JNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism.