Qianqian Zhang , Xia Zhou , Tingting Feng , Hao Tong , Jun Wang , Jianfeng Dai
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引用次数: 0
Abstract
Disease vectors, such as arthropods, primarily rely on innate immunity to counteract pathogen invasions, typically through the recognition and binding of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). As a conserved immune effector gene family from insects to mammals, the complement system may play an essential role in combating pathogenic microorganisms. In arthropods, the complement proteins are often referred to as thioester-containing proteins (TEPs) because thioester motifs are one of the essential functional domains of the first proteins characterized within the C3 and A2M family. TEPs mainly function as specialized PRRs in sensing and binding to pathogens or their components. This paper presents a comprehensive review of the common domain and functions of TEPs in major disease vectors, in particular the specific decision-making ones expressed by Arthropoda (medical arthropods) and Mollusca (Biomphalaria glabrata) after pathogen infections. The relationship between the structure and antibacterial/antiviral activities of TEPs would further our understandings on the mechanisms governing the initiation of innate immune responses in typical disease vectors.
期刊介绍:
This international journal publishes original contributions and mini-reviews in the fields of insect biochemistry and insect molecular biology. Main areas of interest are neurochemistry, hormone and pheromone biochemistry, enzymes and metabolism, hormone action and gene regulation, gene characterization and structure, pharmacology, immunology and cell and tissue culture. Papers on the biochemistry and molecular biology of other groups of arthropods are published if of general interest to the readership. Technique papers will be considered for publication if they significantly advance the field of insect biochemistry and molecular biology in the opinion of the Editors and Editorial Board.