Yao-Yao Zhang, Mattia Ghirardello, Ryan Williams, Adrian Silva Diaz, Javier Rojo, Josef Voglmeir, Javier Ramos-Soriano and M. Carmen Galan*,
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引用次数: 0
Abstract
A continuous microfluidic glycosylation strategy that requires no chromatography between steps and significantly expedites glycosylation chemistry is described. This practical approach incorporates the advantages of imidazolium-based chromatography-free purification and in situ mass spectrometry reaction monitoring to achieve fast reaction optimization and shorter reaction times. We demonstrate the utility of this strategy in the synthesis of a series of glycoside targets, including an α-(1,6)-trimannoside and a branched Man5 oligomannoside, within 1 day.
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