Potential advantage of therapeutic plasma exchange over intravenous immunoglobulin in children with axonal variant of Guillain-Barré syndrome: A report of six paediatric cases

IF 1.4 4区医学 Q4 HEMATOLOGY

Transfusion Clinique et Biologique Pub Date : 2025-02-01 DOI:10.1016/j.tracli.2024.11.005

Joyisa Deb , Gita Negi , Aswin K. Mohan , Indar Kumar Sharawat , Pradip Banerjee , Deepali Chauhan , Daljit Kaur , Ashish Jain

{"title":"Potential advantage of therapeutic plasma exchange over intravenous immunoglobulin in children with axonal variant of Guillain-Barré syndrome: A report of six paediatric cases","authors":"Joyisa Deb , Gita Negi , Aswin K. Mohan , Indar Kumar Sharawat , Pradip Banerjee , Deepali Chauhan , Daljit Kaur , Ashish Jain","doi":"10.1016/j.tracli.2024.11.005","DOIUrl":null,"url":null,"abstract":"<div><div>Guillain-Barre syndrome (GBS) is a disease entity described in literature since 1859. It is associated with various etiological, clinical and immunological factors with prognostic predictive value. Both Intravenous immunoglobulin (IVIG) and Therapeutic Plasma Exchange (TPE) have been regarded as the first-line treatment for GBS. Certain diagnostic tools help us in early identification of GBS subtypes that may aid clinical management. Here, we have discussed six paediatric cases of GBS of Acute Motor Axonal Neuropathy (AMAN) subtype that were considered for TPE. 5 out of 6 patients were eventually weaned from mechanical ventilation and discharged from the hospital. This study emphasizes the role of TPE in management of severe IVIG refractory GBS with axonal involvement that can be beneficial to the patient. TPE may be considered early in GBS cases with axonal involvement.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 112-117"},"PeriodicalIF":1.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transfusion Clinique et Biologique","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1246782024001290","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Guillain-Barre syndrome (GBS) is a disease entity described in literature since 1859. It is associated with various etiological, clinical and immunological factors with prognostic predictive value. Both Intravenous immunoglobulin (IVIG) and Therapeutic Plasma Exchange (TPE) have been regarded as the first-line treatment for GBS. Certain diagnostic tools help us in early identification of GBS subtypes that may aid clinical management. Here, we have discussed six paediatric cases of GBS of Acute Motor Axonal Neuropathy (AMAN) subtype that were considered for TPE. 5 out of 6 patients were eventually weaned from mechanical ventilation and discharged from the hospital. This study emphasizes the role of TPE in management of severe IVIG refractory GBS with axonal involvement that can be beneficial to the patient. TPE may be considered early in GBS cases with axonal involvement.

查看原文本刊更多论文

治疗性血浆置换比静脉注射免疫球蛋白对吉兰-巴雷综合征轴突变异型儿童的潜在优势：六例儿科病例报告

格林-巴利综合征（Guillain-Barre syndrome，GBS）是自 1859 年以来文献中描述的一种疾病实体。它与各种具有预后预测价值的病因学、临床和免疫学因素有关。静脉注射免疫球蛋白（IVIG）和治疗性血浆置换（TPE）一直被视为 GBS 的一线治疗方法。某些诊断工具可以帮助我们早期识别 GBS 亚型，从而有助于临床治疗。在此，我们讨论了六例考虑进行 TPE 治疗的急性运动性轴索神经病（AMAN）亚型 GBS 儿科病例。6 例患者中有 5 例最终脱离了机械通气并出院。这项研究强调了 TPE 在治疗严重的 IVIG 难治性 GBS（伴有轴索受累）中的作用，对患者有益。对于有轴索受累的 GBS 病例，可以尽早考虑使用 TPE。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Transfusion Clinique et Biologique 医学-免疫学

CiteScore

2.50

自引率

11.80%

发文量

234

审稿时长

36 days

期刊介绍： Transfusion Clinique et Biologique, the official journal of the French Society of Blood Transfusion (SFTS): - an aid to training, at a European level - the only French journal indexed in the hematology and immunology sections of Current Contents Transfusion Clinique et Biologique spans fundamental research and everyday practice, with articles coming from both sides. Articles, reviews, case reports, letters to the editor and editorials are published in 4 editions a year, in French or in English, covering all scientific and medical aspects of transfusion: immunology, hematology, infectious diseases, genetics, molecular biology, etc. And finally, a convivial cross-disciplinary section on training and information offers practical updates. Readership: "Transfusers" are many and various: anesthetists, biologists, hematologists, and blood-bank, ICU and mobile emergency specialists...