Emerging pollutants in the aquatic environments: A review of genotoxic impacts

IF 6.4 2区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Juliana Picinini-Zambelli , Ana Letícia Hilário Garcia , Juliana Da Silva
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引用次数: 0

Abstract

Urbanization and industrial growth have negatively impacted water quality, raising concerns about emerging aquatic pollutants. Despite advancements in water treatment, these substances persist, endangering aquatic life and human health. Although research has focused on the physiological effects of these pollutants, their genetic damage potential remains poorly understood. This systematic review aimed to consolidate existing knowledge on the genotoxic potential of emerging aquatic pollutants. A comprehensive search was conducted across major databases, encompassing articles published from 2001 to 2022. The review primarily focused on research articles that evaluated genotoxicity in environmental samples containing emerging pollutants, as well as in vitro studies using various concentrations of these substances. Fourteen articles were included in the review, with pharmaceutical compounds, personal care products, disinfection byproducts, and industrial chemicals being the most extensively investigated classes. Other notable pollutants included metals, cyanotoxins, antiseptics, pesticides, and caffeine. All these pollutants classes were found to cause DNA damage, either in vitro at specific concentrations or in complex environmental mixtures. The comet assay was the most frequently used method, owing to its sensitivity and practicality in assessing DNA damage. For some pollutants, different responses were observed when comparing in vitro and in vivo studies, emphasizing the need for studies employing both approaches. However, the limited number of available articles underscores the necessity for further research on the genotoxic potential of emerging pollutants. More research is required to clarify mutagenicity, DNA repair kinetics, and cumulative effects of pollutants, which are critical for shaping policies and ensuring safe water quality. A greater knowledge about these pollutants will enable better understanding risk mitigation, ultimately protecting public health and ecosystems.
水生环境中新出现的污染物:基因毒性影响综述。
城市化和工业增长对水质产生了负面影响,引起了人们对新出现的水生污染物的关注。尽管水处理技术不断进步,但这些物质依然存在,危及水生生物和人类健康。尽管研究主要集中在这些污染物的生理效应上,但对其潜在的遗传损伤仍知之甚少。本系统综述旨在整合有关新兴水生污染物潜在遗传毒性的现有知识。我们在主要数据库中进行了全面检索,涵盖了 2001 年至 2022 年发表的文章。综述主要侧重于评估含有新出现污染物的环境样本的遗传毒性的研究文章,以及使用这些物质的不同浓度进行的体外研究。综述共收录了 14 篇文章,其中研究最为广泛的是药物化合物、个人护理产品、消毒副产品和工业化学品。其他值得注意的污染物包括金属、氰毒素、杀菌剂、杀虫剂和咖啡因。研究发现,所有这些类别的污染物在特定浓度的体外或复杂的环境混合物中都会造成 DNA 损伤。彗星试验是最常用的方法,因为它在评估 DNA 损伤方面既灵敏又实用。对于某些污染物,在比较体外研究和体内研究时观察到了不同的反应,这就强调了采用这两种方法进行研究的必要性。不过,现有文章数量有限,这突出表明有必要进一步研究新出现的污染物的潜在遗传毒性。需要开展更多的研究来阐明污染物的诱变性、DNA 修复动力学和累积效应,这对于制定政策和确保水质安全至关重要。加深对这些污染物的了解将有助于更好地理解风险缓解问题,最终保护公众健康和生态系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.20
自引率
1.90%
发文量
22
审稿时长
15.7 weeks
期刊介绍: The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.
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