Ferulic acid mitigated rotenone toxicity -Evoked Parkinson in rat model by featuring apoptosis, oxidative stress, and neuroinflammation signaling

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2024-11-16 DOI:10.1016/j.tice.2024.102614

Ola Mohammed Youssef , Nermeen Hosney Lashine , Mohammad El-Nablaway , Mona Ibrahim El-yamany , Manar Monir Youssef , Dina Abdalla Arida

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引用次数: 0

Abstract

Over time, Parkinson disease (PD) develops as a neurological illness. The goal of this study was to see whether ferulic acid has any neuroprotective benefits on the cerebellum of rats that have Parkinson's disease brought on by rotenone poisoning. A total of twenty-four male albino rats, in good condition, weighed between 200 and 250 g and nine to ten weeks old, were employed in the investigation. The control group received 1 ml of sunflower oil intraperitoneally (i.p.) each day. Rats' motor performance was considerably worse when given rotenone than it was in the control group. Rats given Ferulic Acid (FA) showed a substantial drop in the amount of glutathione (GSH) in the cerebellum. Moreover, the injection of FA resulted in a significant reduction in the optical density (OD) of the immune-positive reaction for α-synuclein, and the area percentage of BCL-2 and NF-kB immunological positive response. FA therapy, surprisingly, enhanced the OD of TH immunopositive response and apoptotic regulators (BCL2) in the cerebellum. Furthermore, FA boosted BCL2 expression, confirming the antiapoptotic effects of FA. Based on these results, FA is probably a good candidate to treat neurodegenerative diseases brought on by long-term exposure to rotenone.

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阿魏酸通过抑制细胞凋亡、氧化应激和神经炎症信号传导，减轻鱼藤酮毒性--诱发大鼠帕金森模型。

随着时间的推移，帕金森病（PD）会发展成为一种神经系统疾病。本研究的目的是了解阿魏酸对因鱼藤酮中毒而患帕金森病的大鼠的小脑是否有神经保护作用。本研究共使用了 24 只白化雄性大鼠，它们状况良好，体重在 200 到 250 克之间，9 到 10 周大。对照组每天腹腔注射 1 毫升葵花籽油。与对照组相比，服用鱼藤酮的大鼠的运动表现要差得多。注射阿魏酸（FA）的大鼠小脑中谷胱甘肽（GSH）的含量大幅下降。此外，注射阿魏酸还导致α-突触核蛋白免疫阳性反应的光密度（OD）以及BCL-2和NF-kB免疫阳性反应的面积百分比显著下降。令人惊讶的是，FA疗法增强了小脑中TH免疫阳性反应的OD值和凋亡调节因子（BCL2）。此外，FA还提高了BCL2的表达，证实了FA的抗凋亡作用。基于这些结果，FA可能是治疗长期暴露于鱼藤酮所导致的神经退行性疾病的良好候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.