Severe Periodontitis is Associated With Recurrent Cardiovascular Events-A 10-Year Longitudinal Cohort Study.

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontal research Pub Date : 2024-11-22 DOI:10.1111/jre.13365

Stefan Reichert, Selina Rehm, Axel Schlitt, Susanne Schulz

{"title":"Severe Periodontitis is Associated With Recurrent Cardiovascular Events-A 10-Year Longitudinal Cohort Study.","authors":"Stefan Reichert, Selina Rehm, Axel Schlitt, Susanne Schulz","doi":"10.1111/jre.13365","DOIUrl":null,"url":null,"abstract":"Aim: The study aimed to elucidate a putative association between severe periodontitis and the incidence of recurrent cardiovascular events in patients with cardiovascular disease (CVD) within 10 years after their initial hospitalisation.Methods: A cohort of 1002 stationary patients with angiographically proven CVD was included. They were examined regarding prevalence of severe periodontitis (≥ 30% of the teeth with proximal attachment loss of ≥ 5 mm), probing depth, clinical attachment loss, bleeding on probing, number of missing teeth and oral care habits. Recurrent events were summarised as combined end point (myocardial infarction, stroke/transitory ischemic attack, cardiovascular death and death caused by stroke). Survival analyses were carried out after a 10-year follow-up period. Hazard ratios (HRs) were adjusted for known cardiac risk factors using Cox regression.Results: The follow-up was completed by 792 patients. The overall incidence of the combined end point was 42.8%. Severe periodontitis was associated with recurrent cardiovascular events (adjusted hazard ratio [HR] = 1.26, 95% confidence interval [CI] 1.0-1.58 and Standard error [SE] 0.11), whereas both, tooth brushing more than once a day (adjusted HR = 0.74, 95% CI 0.57-0.97, SE 0.13) and performing interdental hygiene (adjusted HR = 0.71, 95% CI 0.52-0.99, SE 0.16) decreased this risk.Conclusions: Severe periodontitis is a putative risk factor for recurrent cardiovascular events.Trial registration: ClinicalTrials.gov identifier: NCT01045070.","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of periodontal research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/jre.13365","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: The study aimed to elucidate a putative association between severe periodontitis and the incidence of recurrent cardiovascular events in patients with cardiovascular disease (CVD) within 10 years after their initial hospitalisation.

Methods: A cohort of 1002 stationary patients with angiographically proven CVD was included. They were examined regarding prevalence of severe periodontitis (≥ 30% of the teeth with proximal attachment loss of ≥ 5 mm), probing depth, clinical attachment loss, bleeding on probing, number of missing teeth and oral care habits. Recurrent events were summarised as combined end point (myocardial infarction, stroke/transitory ischemic attack, cardiovascular death and death caused by stroke). Survival analyses were carried out after a 10-year follow-up period. Hazard ratios (HRs) were adjusted for known cardiac risk factors using Cox regression.

Results: The follow-up was completed by 792 patients. The overall incidence of the combined end point was 42.8%. Severe periodontitis was associated with recurrent cardiovascular events (adjusted hazard ratio [HR] = 1.26, 95% confidence interval [CI] 1.0-1.58 and Standard error [SE] 0.11), whereas both, tooth brushing more than once a day (adjusted HR = 0.74, 95% CI 0.57-0.97, SE 0.13) and performing interdental hygiene (adjusted HR = 0.71, 95% CI 0.52-0.99, SE 0.16) decreased this risk.

Conclusions: Severe periodontitis is a putative risk factor for recurrent cardiovascular events.

Trial registration: ClinicalTrials.gov identifier: NCT01045070.

查看原文本刊更多论文

严重牙周炎与复发性心血管事件有关--一项为期 10 年的纵向队列研究。

目的：该研究旨在阐明严重牙周炎与心血管疾病（CVD）患者首次住院后 10 年内复发心血管事件发生率之间的假定关联：方法：纳入了 1002 名经血管造影证实患有心血管疾病的固定患者。方法：纳入 1002 名经血管造影证实患有心血管疾病的固定患者，对他们的严重牙周炎患病率（≥ 30% 的牙齿近端附着丧失≥ 5 毫米）、探诊深度、临床附着丧失、探诊出血、缺失牙齿数量和口腔护理习惯进行检查。复发事件汇总为综合终点（心肌梗死、中风/短暂性缺血性发作、心血管死亡和中风导致的死亡）。随访 10 年后进行生存分析。使用 Cox 回归法对已知心脏风险因素的危险比（HRs）进行了调整：结果：792 名患者完成了随访。综合终点的总发病率为 42.8%。严重牙周炎与复发性心血管事件有关（调整后危险比 [HR] = 1.26，95% 置信区间 [CI] 1.0-1.58，标准误差 [SE] 0.11），而每天刷牙超过一次（调整后危险比 = 0.74，95% 置信区间 0.57-0.97，标准误差 0.13）和进行牙间卫生（调整后危险比 = 0.71，95% 置信区间 0.52-0.99，标准误差 0.16）可降低这一风险：结论：严重牙周炎是心血管事件复发的潜在风险因素：试验注册：ClinicalTrials.gov identifier：试验注册：ClinicalTrials.gov identifier：NCT01045070。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of periodontal research 医学-牙科与口腔外科

CiteScore

6.90

自引率

5.70%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.