Impact of demographics and social vulnerability on outcomes in pediatric medullary thyroid cancer

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2024-11-14 DOI:10.1016/j.ijporl.2024.112166

Arifeen Rahman, Christopher Low, Alice Huang, Kara Meister, Karthik Balakrishnan

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引用次数: 0

Abstract

Objective

To evaluate the impact of social vulnerability and social determinants of health on outcomes in pediatric medullary thyroid cancer.

Methods

A SEER database review looking at cases of pediatric medullary thyroid cancer from 1975 to 2016 was conducted and analyzed including data from the American Community Survey.

Results

A total of 174 patients were included in analysis. Five-year overall survival was 97.7 % and the disease specific survival (DSS) was 98.3 %. On univariate analysis, male sex was associated with worsened overall survival (HR = 4.2, CI 1.1–15.5, p < 0.05) but did not reach statistical significance on multivariate analysis. Asian or Pacific Islander race was associated with worsened overall survival on both univariate and multivariate analysis (HR = 5.5, CI 1.4–22.2, p < 0.05). Presenting with localized disease without nodal or distant metastasis was found to be a protective factor (HR = 0.2, CI 0.05–0.53, p < 0.01).

Conclusion

Asian American/Pacific Islander patients and male patients may have poorer survival in pediatric medullary thyroid cancer. More research should be completed to better understand underlying factors.

查看原文本刊更多论文

人口统计学和社会脆弱性对小儿甲状腺髓样癌预后的影响。

目的：评估社会脆弱性和社会健康决定因素对小儿甲状腺髓样癌治疗效果的影响：评估社会脆弱性和健康的社会决定因素对小儿甲状腺髓样癌治疗效果的影响：对1975年至2016年的小儿甲状腺髓样癌病例进行了SEER数据库回顾，并分析了美国社区调查的数据：共有174名患者纳入分析。五年总生存率为97.7%，疾病特异性生存率（DSS）为98.3%。在单变量分析中，男性与总生存率下降有关（HR = 4.2，CI 1.1-15.5，P 结论：男性与总生存率下降有关：亚裔美国人/太平洋岛民患者和男性患者的小儿甲状腺髓样癌生存率可能较低。应开展更多研究，以更好地了解潜在因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.