Individual differences in functional connectivity during suppression of imagined threat.

IF 2.9 2区 医学 Q2 NEUROSCIENCES
Marlon Westhoff, Christoph Vogelbacher, Verena Schuster, Stefan G Hofmann
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引用次数: 0

Abstract

Functional magnetic resonance imaging studies typically rely on between-person analyses. To examine individual differences in functional connectivity, we used Group Iterative Multiple Model Estimation and its subgrouping function to analyze functional magnetic resonance imaging data of 54 participants who were suppressing imagined future threat. A two-stage random-effects meta-analytic approach was employed to examine individual differences. In addition to generalizable connections between brain regions, we identified individual differences in personalized models suggesting different pathways through which individuals suppress future threat. Two subgroups with distinct connectivity patterns emerged: One subgroup (n = 29; 53.70%), characterized by an additional lagged connection from the right to the left posterior cingulate cortex, exhibited comparatively higher anxiety and less brain connectivity, whereas the other subgroup (n = 25; 46.30%), showing an additional connection from the left posterior cingulate cortex to the ventromedial prefrontal cortex, was associated with lower anxiety levels and greater connectivity. This study points to individual differences in functional connectivity during emotion regulation.

抑制想象威胁时功能连接的个体差异。
功能磁共振成像研究通常依赖于人与人之间的分析。为了研究功能连通性的个体差异,我们使用了群体迭代多重模型估计及其分组功能,分析了 54 名抑制想象的未来威胁的参与者的功能磁共振成像数据。我们采用了两阶段随机效应荟萃分析方法来研究个体差异。除了大脑区域之间可通用的连接外,我们还发现了个性化模型中的个体差异,这表明个体抑制未来威胁的途径不同。我们发现了两个具有不同连接模式的亚组:一个亚组(n = 29;53.70%)的特点是从右侧到左侧扣带回后皮层的额外滞后连接,表现出相对较高的焦虑水平和较低的大脑连接性;而另一个亚组(n = 25;46.30%)则表现出从左侧扣带回后皮层到腹内侧前额叶皮层的额外连接,与较低的焦虑水平和较高的连接性相关。这项研究表明,情绪调节过程中的功能连接存在个体差异。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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