The role of macrophages in chronic pain

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-11-22 DOI:10.1016/j.cyto.2024.156813

Weikang Tang, Xuan Li, Huixia Liu, Chunyan Xu, Siyao Deng

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引用次数: 0

Abstract

Chronic pain typically lasts or recurs for more than three months and is an unpleasant sensory and emotional experience, including neuropathic pain, long-term tissue damage, tumors, and viral or bacterial infections.The unpleasantness associated with pain affects the basic life of patients and has become a truly global problem. Macrophages, a powerful immune effector cell whose functional plasticity leads to polarization into different subtypes and opposite effects in different environments, are also indispensable in the development of pain.In recent years, there has been an increasing number of studies on the effects of macrophages on pain, and there are multiple pathways that regulate macrophage polarization, including lipopolysaccharide induction and IL-4/IL-13 stimulation.In addition, pathways involving macrophages and macrophage polarization have been found to have an exacerbating or mitigating role in the progression of chronic pain, with M1 macrophages generally exacerbating pain progression and M2 macrophages mitigating pain progression.Therefore, modulating macrophage polarization holds great promise as an intervention in chronic pain. In this paper, we synthesize multiple macrophage pathways as well as mechanisms affecting their pain processes in the context of different types of chronic pain, providing new avenues for chronic pain relief.

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巨噬细胞在慢性疼痛中的作用

慢性疼痛通常持续或复发三个月以上，是一种不愉快的感官和情绪体验，包括神经病理性疼痛、长期组织损伤、肿瘤、病毒或细菌感染等。疼痛带来的不愉快影响了患者的基本生活，已成为一个真正的全球性问题。巨噬细胞是一种强大的免疫效应细胞，其功能的可塑性导致巨噬细胞极化为不同的亚型，并在不同的环境中发挥相反的作用，在疼痛的发生发展过程中也是不可或缺的。近年来，关于巨噬细胞对疼痛影响的研究越来越多，巨噬细胞极化的调控途径有多种，包括脂多糖诱导和IL-4/IL-13刺激。此外，涉及巨噬细胞和巨噬细胞极化的途径已被发现在慢性疼痛的进展中具有加重或减轻的作用，其中M1巨噬细胞通常会加重疼痛的进展，而M2巨噬细胞则会减轻疼痛的进展。因此，调节巨噬细胞极化作为慢性疼痛的干预措施具有很大的前景。本文综述了巨噬细胞的多种通路以及在不同类型的慢性疼痛中影响其疼痛过程的机制，为慢性疼痛的缓解提供了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.