The pattern of childhood infections during and after the COVID-19 pandemic

IF 19.9 1区医学 Q1 PEDIATRICS

Lancet Child & Adolescent Health Pub Date : 2024-11-19 DOI:10.1016/S2352-4642(24)00236-0

Ulrikka Nygaard PhD , Mette Holm PhD , Prof Helena Rabie PhD , Maren Rytter PhD

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引用次数: 0

Abstract

The rates of most paediatric infectious diseases declined during the initial phase of the COVID-19 pandemic due to the implementation of non-pharmaceutical interventions. However, after the gradual release of these interventions, resurgences of infections occurred with notable variations in incidence, clinical manifestations, pathogen strains, and age distribution. This Review seeks to explore these changes and the rare clinical manifestations that were made evident during the resurgence of known childhood infections. The magnitude of resurgences was possibly caused by a profound population immunity debt to specific pathogens in combination with the coinciding reappearance of viral and bacterial infections, rather than novel pathogen variants, increased antimicrobial resistance, or altered childhood immune function. As the usual patterns of paediatric infectious diseases were disrupted during the COVID-19 pandemic, the consequences of a population immunity debt were unravelled, and new insights into pathogen transmissibility, disease pathogenesis, and rare clinical manifestations were revealed.

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COVID-19 大流行期间和之后的儿童感染模式。

在 COVID-19 大流行的初期阶段，由于实施了非药物干预措施，大多数儿科传染病的发病率有所下降。然而，在这些干预措施逐渐解除后，感染又重新出现，并在发病率、临床表现、病原体菌株和年龄分布方面出现了明显的变化。本综述旨在探讨这些变化以及在已知儿童感染死灰复燃期间明显出现的罕见临床表现。再次爆发的严重程度可能是由于人群对特定病原体的免疫力严重不足，再加上病毒和细菌感染同时再次出现，而不是由于新型病原体变异、抗菌药耐药性增加或儿童免疫功能改变。在 COVID-19 大流行期间，儿科传染病的惯常模式被打破，人群免疫债务的后果被揭开，病原体的可传播性、疾病发病机制和罕见临床表现也有了新的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Child & Adolescent Health Psychology-Developmental and Educational Psychology

CiteScore

40.90

自引率

0.80%

发文量

381

期刊介绍： The Lancet Child & Adolescent Health, an independent journal with a global perspective and strong clinical focus, presents influential original research, authoritative reviews, and insightful opinion pieces to promote the health of children from fetal development through young adulthood. This journal invite submissions that will directly impact clinical practice or child health across the disciplines of general paediatrics, adolescent medicine, or child development, and across all paediatric subspecialties including (but not limited to) allergy and immunology, cardiology, critical care, endocrinology, fetal and neonatal medicine, gastroenterology, haematology, hepatology and nutrition, infectious diseases, neurology, oncology, psychiatry, respiratory medicine, and surgery. Content includes articles, reviews, viewpoints, clinical pictures, comments, and correspondence, along with series and commissions aimed at driving positive change in clinical practice and health policy in child and adolescent health.