Polyphenol Supplementation and Sarcopenia: A Systematic Review and Meta-Analysis of Clinical Trials.

IF 3.3 Q2 GERIATRICS & GERONTOLOGY

Journal of Frailty & Aging Pub Date : 2024-01-01 DOI:10.14283/jfa.2024.73

A Medoro, G Scapagnini, S Davinelli

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引用次数: 0

Abstract

Background: Experimental evidence suggests that polyphenols, a large group of phytochemicals found in fruits and vegetables, may preserve muscle mass and strength by increasing the expression of anabolic factors and enhancing mitochondrial function.

Objectives: This systematic review and meta-analysis aims to summarize the evidence about the effect of polyphenol supplementation on muscle mass, muscle strength, and physical performance in individuals with sarcopenia.

Methods: A systematic search was conducted using three databases (PubMed/Medline, Scopus, and Web of Science) from the date of inception to April 2024. Interventional studies examining the effect of polyphenol supplementation on muscle measures and physical performance in middle-aged and older subjects with sarcopenia were included.

Results: Of the 344 articles screened, 7 articles were included in the systematic review. Five of the 7 included studies were meta-analyzed, involving a total of 227 patients with sarcopenia. The results showed a statistically significant effect of polyphenols on muscle mass (SMD = 1.50; 95% CI: 0.26, 2.75; Z = 2.36; P = 0.02), no effect on muscle strength (SMD = 0.03; 95% CI: -0.24, 0.30; Z = 0.20; P = 0.84), and a near-significant trend on physical performance (SMD = 0.52; 95% CI: -0.03, 1.07; P = 0.06).

Conclusions: Based on the available data, this study provides pooled evidence that treatment with polyphenols may have a beneficial effect on muscle mass in sarcopenic subjects. However, further studies with larger sample sizes are required to substantiate this effect and draw more accurate conclusions.

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多酚补充剂与 "肌肉疏松症"：临床试验的系统回顾与元分析》。

背景：实验证据表明，多酚是水果和蔬菜中的一大类植物化学物质，可通过增加合成代谢因子的表达和增强线粒体功能来保持肌肉质量和力量：本系统综述和荟萃分析旨在总结有关补充多酚对肌肉疏松症患者的肌肉质量、肌肉力量和身体表现的影响的证据：方法：我们使用三个数据库（PubMed/Medline、Scopus 和 Web of Science）进行了系统性检索，检索时间从开始日期到 2024 年 4 月。结果：在筛选出的 344 篇文章中，有 3 篇文章探讨了多酚补充剂对中老年肌肉疏松症患者肌肉指标和体能表现的影响：结果：在筛选出的 344 篇文章中，有 7 篇被纳入系统综述。对纳入的 7 项研究中的 5 项进行了元分析，共涉及 227 名肌肉疏松症患者。结果显示，多酚对肌肉质量的影响具有统计学意义（SMD = 1.50；95% CI：0.26, 2.75；Z = 2.36；P = 0.02），对肌肉力量无影响（SMD = 0.03；95% CI：-0.24, 0.30；Z = 0.20；P = 0.84），对体能表现有接近显著的趋势（SMD = 0.52；95% CI：-0.03, 1.07；P = 0.06）：根据现有数据，本研究提供的综合证据表明，使用多酚治疗可能会对肌肉疏松受试者的肌肉质量产生有益影响。然而，要证实这种效果并得出更准确的结论，还需要进行样本量更大的进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-

CiteScore

5.90

自引率

7.70%

发文量

期刊介绍： The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).