A noninvasive ultrasound vibro-elastography technique for assessing ocular lesions

IF 3.8 2区物理与天体物理 Q1 ACOUSTICS

Ultrasonics Pub Date : 2024-11-19 DOI:10.1016/j.ultras.2024.107525

Ngoc Thang Bui , Lauren A. Dalvin , Shannon L. Howard , Jason P. Hall , Arthur J. Sit , Xiaoming Zhang

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引用次数: 0

Abstract

Objective

This research aims to develop a noninvasive ultrasound vibro-elastography technique for assessing ocular lesions including intraocular melanoma and nevus lesions.

Method

Wave speed (WS) was noninvasively measured in the lesions at three different frequencies (i.e., 100 Hz, 150 Hz, and 200 Hz). The nearby normal tissue of choroid and sclera was also analyzed as controls. Viscoelasticity of these tissues was analyzed using the wave speed dispersion curve and the Voigt model.

Results

In this pilot study of 10 cases (5 melanomas vs. 5 nevus) with ages (mean ± SD) of (53.2 ± 6.82) vs. (72.2 ± 7.71) yo, the WS (m/s), elasticity (kPa) and viscosity (Pa.s) of lesion (melanoma vs. nevus) locations of the eye (i.e., WS @100 Hz: 3.63 vs. 3.09 (m/s), @150 Hz: 4.10 vs. 3.66 (m/s), @200 Hz: 4.78 vs. 4.07 (m/s); elasticity: 9.59 vs. 6.89 (kPa); viscosity: 12.46 vs. 9.26(Pa.s)) were analyzed. There were significant differences of WS ratio (WS close to the surface and WS inside the tumor) between the nevus and melanoma of all three frequencies (i.e., nevus vs. melanoma; @100 Hz: 1.59 vs. 2.95, p = 0.0285; @150 Hz: 1.58 vs. 3.53, p = 0.0054; @200 Hz: 1.70 vs. 3.31, p = 0.0124). The melanoma lesions are stiffer than the nevus lesions. It also shows that the lesion tissues are stiffer than the control tissues. However, there were no significant differences in WS, elasticity, viscosity among melanoma lesions, nevus lesions, and control tissues.

Conclusions

We demonstrate for the first time that noninvasive ultrasound vibro-elastography can be used for assessing ocular lesions. The results show that lesion tissues are stiffer than control tissues. They also show that melanoma lesions are stiffer than the nevus lesions. We plan to study more ocular lesion patients and improve the specificity and sensitivity of wave speed or viscoelasticity between lesions and controls.

Significance

Ultrasound vibro-elastography is an innovative and noninvasive technique for assessing ocular lesions.

查看原文本刊更多论文

用于评估眼部病变的无创超声振动弹性成像技术。

研究目的本研究旨在开发一种无创超声振动弹性成像技术，用于评估眼部病变，包括眼内黑色素瘤和痣病变：方法：以三种不同频率（即 100 Hz、150 Hz 和 200 Hz）无创测量病变部位的波速（WS）。同时还分析了附近的脉络膜和巩膜正常组织作为对照。利用波速频散曲线和 Voigt 模型分析了这些组织的粘弹性：在这项对年龄（平均 ± SD）为（53.2 ± 6.82）岁和（72.2 ± 7.71）岁的 10 个病例（5 个黑色素瘤与 5 个痣对比）进行的试点研究中，眼部病变（黑色素瘤与痣对比）位置的波速（m/s）、弹性（kPa）和粘度（Pa.s）（即波速 @100 Hz：3.63 vs. 3.09 (m/s), @150 Hz：4.10 vs. 3.66 (m/s), @200 Hz：4.78 vs. 4.07（m/s）；弹性：9.59 vs. 6.89（kPa）；粘度：12.46 vs. 9.26（Pa.s））进行了分析。在三种频率下，痣和黑色素瘤的 WS 比值（靠近瘤体表面的 WS 和瘤体内的 WS）均有明显差异（即痣 vs. 黑色素瘤；@100 Hz：1.59 vs. 2.95, p = 0.0285; @150 Hz：1.58 vs. 3.53, p = 0.0054; @200 Hz：1.70 vs. 3.31，p = 0.0124）。黑色素瘤病变比痣病变更硬。这也表明病变组织比对照组组织更硬。然而，黑色素瘤病变组织、痣病变组织和对照组织的 WS、弹性和粘度没有明显差异：我们首次证明了无创超声振动弹性成像技术可用于评估眼部病变。结果显示，病变组织比对照组织更硬。结果还显示，黑色素瘤病变组织比痣病变组织更硬。我们计划研究更多的眼部病变患者，并提高病变组织与对照组织之间波速或粘弹性的特异性和敏感性：超声振动弹性成像技术是评估眼部病变的一种创新性无创技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonics 医学-核医学

CiteScore

7.60

自引率

19.00%

发文量

186

审稿时长

3.9 months

期刊介绍： Ultrasonics is the only internationally established journal which covers the entire field of ultrasound research and technology and all its many applications. Ultrasonics contains a variety of sections to keep readers fully informed and up-to-date on the whole spectrum of research and development throughout the world. Ultrasonics publishes papers of exceptional quality and of relevance to both academia and industry. Manuscripts in which ultrasonics is a central issue and not simply an incidental tool or minor issue, are welcomed. As well as top quality original research papers and review articles by world renowned experts, Ultrasonics also regularly features short communications, a calendar of forthcoming events and special issues dedicated to topical subjects.