Genus Bauhinia (Fabaceae): A review from phytochemistry to pharmacology- Exploring traditional uses and toxicological insights across Asia.

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2024-11-12 DOI:10.1016/j.phymed.2024.156246

Rupali Verma, Shubham Dash, Ankita, Shorya Thakur, Rajesh Kumar, Gurvinder Singh, Charanjit Kaur

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引用次数: 0

Abstract

Background: The genus Bauhinia and its species has been known since ages by tribal people and medicinal practitioners in tropical and subtropical regions for the treatment of diabetes, diarrhea, cough, fever, stomach disorders, skin diseases, and other diseases.

Study design: Our aim was to collect and explore the literature available on the traditional applications and medicinal potential of genus Bauhinia across Asia, so that this review can be used as standard to analyze the immense potential of this genus and can be explored further for clinical use.

Methods: The information was rigorously gathered from Google Scholar, Pub Med, Elsevier, Wiley Online Search, Science Direct, and other literature sources.

Results: As per the literature, this genus possesses antimicrobial, antioxidant, nephroprotective, anticancer, hepatoprotective, antidiabetic, anti-inflammatory, and antidepressant activities both in vitro and in vivo, due to the presence of flavonoids, steroidal saponins, bauhinioxepins, chromanones, and phenolic compounds.

Conclusion: In this review, we have detailed for the first time the categorized information about traditional uses, geographical distribution, morphological features, phytochemistry, pharmacological, and toxicological effects, and patents associated with Bauhinia species. However, more research is needed to explore the mechanisms of action, pharmacokinetics of the phytoconstituents, and clinical evaluation for their future use in treating various ailments.

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紫荆属（豆科）：从植物化学到药理学的综述--探索亚洲各地的传统用途和毒理学见解。

背景：紫荆属及其物种自古以来就被热带和亚热带地区的部落居民和药剂师用于治疗糖尿病、腹泻、咳嗽、发烧、胃病、皮肤病和其他疾病：研究设计：我们的目的是收集和探索有关亚洲各地紫荆属植物的传统应用和药用潜力的文献，以便将本综述作为分析该属植物巨大潜力的标准，并进一步探索其临床应用：方法：从 Google Scholar、Pub Med、Elsevier、Wiley Online Search、Science Direct 和其他文献来源严格收集信息：根据文献资料，该属植物由于含有黄酮类、甾体皂苷类、紫荆素类、色酮类和酚类化合物，在体外和体内均具有抗菌、抗氧化、保护肾脏、抗癌、保肝、抗糖尿病、抗炎和抗抑郁等活性：在这篇综述中，我们首次详细介绍了有关洋紫荆物种的传统用途、地理分布、形态特征、植物化学、药理和毒理作用以及相关专利的分类信息。然而，还需要进行更多的研究，以探索植物成分的作用机制、药代动力学以及临床评估，以便将来用于治疗各种疾病。

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.