The association of obesity and the risk of rheumatoid arthritis according to abdominal obesity status: a nationwide population-based study in Korea.

IF 3.2 3区医学 Q2 RHEUMATOLOGY

Rheumatology International Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI:10.1007/s00296-024-05748-5

Jung Sun Lee, Ji Seon Oh, Sehee Kim, Ye-Jee Kim, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo

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引用次数: 0

Abstract

Objectives: This study aimed to assess the association between obesity or changes in body mass index (BMI) and the risk of RA considering the abdominal obesity status.

Methods: We included individuals aged 23 to 60 who underwent a national health examination in 2012-2013 (baseline) and four years prior. Obesity was defined by a BMI ≥ 25 kg/m². The change in BMI over 4 years was divided into quartiles. Cox proportional hazard analysis was performed to assess the association of obesity and BMI change with the risk of RA.

Results: A total of 6,207,246 subjects were included, and 7,859 incident cases of RA were identified. Obesity was associated with a reduced risk of RA in males (HR 0.78, 95% CI 0.71-0.85) and females (HR 0.91, 95% CI 0.85-0.97). In subgroup analysis according to abdominal obesity status, the associations were observed for obesity with normal waist circumference (WC) in males (HR 0.75, 95% CI 0.67-0.84) and females (HR 0.88, 95% CI 0.81-0.95). In terms of BMI change, compared to the stable BMI group (quartile 2), the third (HR 0.92, CI 0.85-0.99) and highest quartile (HR 0.89, CI 0.83-0.96) showed an inverse association with the risk of RA in females, particularly in those with normal WC.

Conclusion: Obesity was associated with a lower risk of RA, especially among individuals with a normal WC. Increased BMI was also associated with a lower risk of RA, but this association was mainly observed in females and specifically for those with normal WC.

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腹部肥胖状况与肥胖和类风湿性关节炎风险的关系：韩国一项全国性人口研究。

研究目的本研究旨在评估肥胖或体重指数（BMI）变化与 RA 风险之间的关联，同时考虑腹部肥胖状况：我们纳入了在2012-2013年（基线）和四年前接受过国民健康检查的23至60岁的人群。肥胖的定义是体重指数（BMI）≥ 25 kg/m2。4 年间体重指数的变化分为四等分。对肥胖和 BMI 变化与 RA 风险的关系进行了 Cox 比例危险分析：结果：共纳入了 6,207,246 名受试者，发现了 7,859 例 RA 发病病例。肥胖与男性（HR 0.78，95% CI 0.71-0.85）和女性（HR 0.91，95% CI 0.85-0.97）罹患 RA 的风险降低有关。在根据腹部肥胖状况进行的亚组分析中，观察到男性（HR 0.75，95% CI 0.67-0.84）和女性（HR 0.88，95% CI 0.81-0.95）腰围（WC）正常的肥胖者存在相关性。就体重指数变化而言，与体重指数稳定组（第二四分位数）相比，第三四分位数（HR 0.92，CI 0.85-0.99）和最高四分位数（HR 0.89，CI 0.83-0.96）与女性罹患RA的风险呈负相关，尤其是在腹围正常者中：结论：肥胖与罹患 RA 的风险较低有关，尤其是在腹围正常的人群中。体重指数（BMI）的升高也与罹患 RA 的风险降低有关，但这种关联主要出现在女性身上，尤其是在腹围正常的人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rheumatology International 医学-风湿病学

CiteScore

7.30

自引率

5.00%

发文量

191

审稿时长

16. months

期刊介绍： RHEUMATOLOGY INTERNATIONAL is an independent journal reflecting world-wide progress in the research, diagnosis and treatment of the various rheumatic diseases. It is designed to serve researchers and clinicians in the field of rheumatology. RHEUMATOLOGY INTERNATIONAL will cover all modern trends in clinical research as well as in the management of rheumatic diseases. Special emphasis will be given to public health issues related to rheumatic diseases, applying rheumatology research to clinical practice, epidemiology of rheumatic diseases, diagnostic tests for rheumatic diseases, patient reported outcomes (PROs) in rheumatology and evidence on education of rheumatology. Contributions to these topics will appear in the form of original publications, short communications, editorials, and reviews. "Letters to the editor" will be welcome as an enhancement to discussion. Basic science research, including in vitro or animal studies, is discouraged to submit, as we will only review studies on humans with an epidemological or clinical perspective. Case reports without a proper review of the literatura (Case-based Reviews) will not be published. Every effort will be made to ensure speed of publication while maintaining a high standard of contents and production. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.