Myocardial Performance Index to assess cardiac function in autoimmune connective tissue disease: a systematic review and meta-analysis.

IF 3.7 2区医学 Q1 RHEUMATOLOGY

Lupus Science & Medicine Pub Date : 2024-11-20 DOI:10.1136/lupus-2024-001272

Rudy Hidayat, Sally Aman Nasution, Faisal Parlindungan, Naomi Niari Dalimunthe, Steven Alvianto, Nicolas Daniel Widjanarko, Ummi Kultsum, Cristopher Efendi, Yovita Gotama

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引用次数: 0

Abstract

Objectives: This study aimed to evaluate cardiac function using Myocardial Performance Index (MPI) in autoimmune connective tissue disease (ACTD) patients without cardiovascular abnormalities.

Methods: A systematic search of databases including Medline, Google Scholar, ProQuest, Scopus and Cochrane Library was conducted to identify relevant studies on ACTD and MPI from 1995 to 2023. ACTD included in the search were rheumatoid arthritis (RA), systemic sclerosis (SSc), systemic lupus erythematosus (SLE), Sjögren syndrome (SjD), polymyositis and dermatomyositis. Quality assessment was performed using the Newcastle-Ottawa Scale, followed by meta-analysis computation of mean differences (MDs) of MPI using Review Manager V.5.4.

Results: A total of 22 studies for qualitative and 19 for quantitative synthesis were included. We found six studies on RA, eight studies on SSc, five studies on SLE, two studies on SjD and one on mixed connective tissue disorder. Conventional echocardiography and tissue Doppler imaging (TDI) were used to assess the MPI. Both conventional MPI and tissue Doppler MPI values were elevated compared with healthy control (MD=0.11, 95% CI 0.08 to 0.14, p value<0.00001 and MD=0.06, 95% CI 0.03 to 0.10, p value=0.00001, respectively).

Conclusions: We found elevated MPI values in patients with ACTD compared with healthy controls. MPI assessment has the potential for early detection and management of cardiac dysfunction in patients with ACTD, but further studies are required to corroborate these findings.

Prospero registration number: CRD42023490643.

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评估自身免疫性结缔组织病心功能的心肌功能指数：系统综述和荟萃分析。

研究目的本研究旨在使用心肌功能指数（MPI）评估无心血管异常的自身免疫性结缔组织病（ACTD）患者的心脏功能：对 Medline、Google Scholar、ProQuest、Scopus 和 Cochrane Library 等数据库进行了系统检索，以确定 1995 年至 2023 年间有关 ACTD 和 MPI 的相关研究。搜索的 ACTD 包括类风湿性关节炎 (RA)、系统性硬化症 (SSc)、系统性红斑狼疮 (SLE)、Sjögren 综合征 (SjD)、多发性肌炎和皮肌炎。使用纽卡斯尔-渥太华量表进行质量评估，然后使用Review Manager V.5.4进行荟萃分析，计算MPI的平均差（MDs）：共纳入 22 项定性研究和 19 项定量综合研究。我们发现了 6 项关于 RA 的研究、8 项关于 SSc 的研究、5 项关于系统性红斑狼疮的研究、2 项关于 SjD 的研究和 1 项关于混合性结缔组织病的研究。常规超声心动图和组织多普勒成像（TDI）用于评估 MPI。与健康对照组相比，常规 MPI 和组织多普勒 MPI 值均升高（MD=0.11，95% CI 0.08 至 0.14，P 值）：我们发现，与健康对照组相比，ACTD 患者的 MPI 值升高。MPI评估具有早期发现和管理ACTD患者心脏功能障碍的潜力，但还需要进一步的研究来证实这些发现：CRD42023490643。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lupus Science & Medicine RHEUMATOLOGY-

CiteScore

5.30

自引率

7.70%

发文量

审稿时长

15 weeks

期刊介绍： Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.