The safety and effectiveness of 40 Hz γ-tACS in Alzheimer's disease: A meta-analysis.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-11-01 Epub Date: 2024-10-29 DOI:10.1177/13872877241289397

Xinyang Zhang, Renhua Lv, Yanqiu Sun, Timon Cheng-Yi Liu

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Abstract

Background: The efficacy and safety of 40 Hz gamma transcranial alternating current stimulation (γ-tACS) in Alzheimer's disease (AD) are still uncertain.

Objective: This meta-analysis was conducted to investigate the therapeutic potential and safety of 40 Hz γ-tACS for AD.

Methods: The meta-analysis was conducted by systematically searching four databases from their start to 28 December 2023. Subgroup analyses were performed to identify the intervention effects of γ-tACS.

Results: Of the 7 included studies, γ-tACS has a notable impact on improving overall cognition [standardized mean difference (SMD): 0.49, 95% CI: 0.09 to 0.89], memory (SMD: 0.79, 95% CI: 0.18 to 1.41), and cholinergic transmission (weighted mean difference: -0.40, 95% CI: -0.43 to -0.37). Furthermore, subgroup analysis revealed that γ-tACS treatment had a substantial impact on enhancing memory targeting the left angular gyrus in both home (SMD: 3.12, 95% CI: 1.54 to 4.70) and non-home settings (SMD: 0.53, 95% CI: 0.24 to 0.82). However, γ-tACS had a positive effect on overall cognition in non-home settings (SMD: 0.55, 95% CI 0.11 to 0.98), but not in home settings (SMD: 0.22, 95% CI -0.76 to 1.20). Additionally, targeting temporo-frontal or bitemporal γ-tACS treatment resulted in improvement in overall cognition (SMD: 0.61, 95% CI: 0.06 to 1.16), but not targeting the left angular gyrus (SMD: 0.22, 95% CI: -0.76 to 1.20).

Conclusions: γ-tACS could be beneficial in enhancing cognition, memory and restoring cholinergic dysfunction in AD. The different selection of stimulation sites plays distinct roles. Meanwhile, AD patients are recommended to receive γ-tACS treatment at home.

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40 Hz γ-tACS 对阿尔茨海默病的安全性和有效性：荟萃分析

背景：40赫兹γ经颅交变电流刺激（γ-tACS）对阿尔茨海默病（AD）的疗效和安全性仍不确定：本荟萃分析旨在研究 40 赫兹γ-tACS 对阿尔茨海默病（AD）的治疗潜力和安全性：方法：荟萃分析通过系统检索四个数据库（从开始到 2023 年 12 月 28 日）进行。为了确定γ-tACS的干预效果，进行了分组分析：在纳入的 7 项研究中，γ-tACS 对改善整体认知[标准化平均差（SMD）：0.49，95% CI：0.09 至 0.89]、记忆（SMD：0.79，95% CI：0.18 至 1.41）和胆碱能传递（加权平均差：-0.40，95% CI：-0.43 至 -0.37）有显著影响。此外，亚组分析表明，γ-tACS 治疗对增强家庭（SMD：3.12，95% CI：1.54 至 4.70）和非家庭环境（SMD：0.53，95% CI：0.24 至 0.82）中以左侧角回为目标的记忆有很大影响。然而，γ-tACS 对非居家环境中的总体认知能力有积极影响（SMD：0.55，95% CI 0.11 至 0.98），但对居家环境中的总体认知能力没有积极影响（SMD：0.22，95% CI -0.76 至 1.20）。此外，针对颞额叶或颞位的γ-tACS治疗可改善整体认知能力（SMD：0.61，95% CI：0.06至1.16），但针对左侧角回的治疗效果不佳（SMD：0.22，95% CI：-0.76至1.20）。结论：γ-tACS 对增强 AD 患者的认知、记忆和恢复胆碱能功能障碍有益，刺激部位的不同选择发挥着不同的作用。同时，建议 AD 患者在家中接受 γ-tACS 治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.