Scavenger receptor-A is a sensitive disease activity biomarker in ESR and CRP normal rheumatoid arthritis

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2024-11-22 DOI:10.1111/1756-185X.15404

Shixiong Cao, Xu Liu, Yang Xie, Fanlei Hu, Zhanguo Li, Yin Su, Li Luo, Xiaolin Sun

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引用次数: 0

Abstract

Objective

Identification of rheumatoid arthritis (RA) patients in active disease with normal ESR and CRP is a challenge in disease activity assessment. The objective of this study was to evaluate the performance and clinical significance of Scavenger receptor-A (SRA) as a disease activity biomarker in RA, especially in ESR and CRP normal patients.

Methods

One hundred and sixty-two RA (40 discovery cohort; 122 validation cohort), 20 osteoarthritis (OA), and 36 healthy controls (HCs) were recruited. Ten disease activity markers were evaluated by Bio-Plex Pro Human Cytokine Assay in the discovery cohort. SRA levels were measured by enzyme-linked immunosorbent assay (ELISA) in the validation cohort. The association between SRA and clinical phenotypes was also analyzed. ROC analysis was performed for disease activity prediction.

Results

SRA was found to be correlated with disease activity in the discovery cohort. The serum SRA level was verified by ELISA in the validation cohort, and was found to be correlated with disease activity index in RA patients, including DAS28-ESR (r = .477, p < .001), swollen joint counts, and tender joint counts; as well as inflammation markers, including ESR and CRP. In ESR and CRP normal RA, there was a strong correlation between SRA and DAS28-ESR ( $χ^{2}$ = 4.564, p = .003). In addition, area under the ROC of SRA was higher than AUC_ESR and AUC_CRP in ESR and CRP normal RA patients, suggesting that serum SRA could be more sensitive than ESR and CRP for disease activity assessment in this group of patients. In the low DAS28-ESR (≤3.2) group, the AUC of SRA for disease activity measurement was higher than that of ESR and CRP, indicating that SRA was also more sensitive than ESR and CRP in low-disease activity RA.

Conclusion

SRA was correlated with RA disease activity and may be a sensitive serum biomarker for disease activity evaluation, especially in ESR and CRP normal patients, as well as in the low-disease activity group. SRA could be a promising marker for disease activity assessment.

查看原文本刊更多论文

清道夫受体-A 是 ESR 和 CRP 正常类风湿性关节炎的敏感疾病活动生物标志物。

目的：类风湿关节炎（RA）患者的血沉（ESR）和血清反应蛋白（CRP）正常但疾病处于活动期，如何鉴别这些患者是疾病活动性评估的一项挑战。本研究旨在评估清道夫受体-A（SRA）作为类风湿关节炎疾病活动性生物标志物的性能和临床意义，尤其是在血沉和 CRP 正常的患者中：招募了 162 名 RA（40 名发现队列；122 名验证队列）、20 名骨关节炎（OA）和 36 名健康对照（HC）。在发现队列中，用 Bio-Plex Pro 人类细胞因子测定法评估了 10 种疾病活动性标志物。在验证队列中，通过酶联免疫吸附试验（ELISA）测量了 SRA 水平。此外，还分析了 SRA 与临床表型之间的关联。对疾病活动性预测进行了 ROC 分析：结果：在发现队列中发现 SRA 与疾病活动性相关。在验证队列中，血清SRA水平经ELISA验证，发现与RA患者的疾病活动指数相关，包括DAS28-ESR（r = .477，p χ 2 $$ {\chi}^2 $$ = 4.564，p = .003）。此外，在血沉和CRP正常的RA患者中，SRA的ROC下面积高于AUCESR和AUCCRP，这表明血清SRA比血沉和CRP对该组患者的疾病活动性评估更敏感。在低DAS28-ESR（≤3.2）组中，SRA对疾病活动性测量的AUC高于ESR和CRP，表明SRA对低疾病活动性RA的敏感性也高于ESR和CRP：结论：SRA与RA疾病活动性相关，可能是评估疾病活动性的敏感血清生物标记物，尤其是在血沉和CRP正常的患者以及低疾病活动性组中。SRA可能是一种有前途的疾病活动性评估标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.