Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion.

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2024-11-22 DOI:10.1007/s11883-024-01250-2

Ying Cao, Yanyan Yang, Chuan Guo, Jinbao Zong, Min Li, Xiaolu Li, Tao Yu

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引用次数: 0

Abstract

Purpose of review: RNA-binding proteins (RBPs) have emerged as crucial regulators of post-transcriptional processes, influencing the fate of RNA. This review delves into the biological functions of RBPs and their role in alternative splicing concerning atherosclerosis (AS), highlighting their participation in essential cellular processes. Our goal is to offer new insights for cardiovascular disease research and treatment.

Recent finding: Dysregulation of RBPs is associated with various human diseases, including autoimmune and neurological disorders. The role of RBPs in the pathogenesis of AS is progressively being elucidated, as they influence plaque formation and disease progression by regulating cell function and gene expression. RBPs play intricate biological roles in regulating pre-mRNA, including editing, splicing, stability and translation. Alternative splicing has been demonstrated to enhance biological complexity and diversity. Our findings indicate that alternative splicing is extensively involved in the pathogenesis of AS. The dysregulated expression of specific RBPs in AS is linked to the production of adhesion molecules and vascular endothelium damage. Further research on RBPs could pave the way for the development of novel therapeutic targets.

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RNA 结合蛋白在调节细胞粘附、动脉粥样硬化斑块进展和斑块侵蚀中的作用

综述的目的：RNA 结合蛋白（RBPs）已成为转录后过程的关键调节因子，影响着 RNA 的命运。这篇综述深入探讨了 RBPs 的生物学功能及其在有关动脉粥样硬化（AS）的替代剪接中的作用，强调了它们在重要细胞过程中的参与。我们的目标是为心血管疾病的研究和治疗提供新的见解：最新发现：RBPs 的失调与多种人类疾病有关，包括自身免疫性疾病和神经系统疾病。RBPs通过调节细胞功能和基因表达影响斑块的形成和疾病的进展，其在强直性脊柱炎发病机制中的作用正逐步得到阐明。RBPs 在调节前核糖核酸方面发挥着复杂的生物学作用，包括编辑、剪接、稳定性和翻译。替代剪接已被证明能提高生物的复杂性和多样性。我们的研究结果表明，替代剪接广泛参与了强直性脊柱炎的发病机制。强直性脊柱炎中特定 RBPs 的表达失调与粘附分子的产生和血管内皮损伤有关。对RBPs的进一步研究可为开发新的治疗靶点铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.