Orbital granular cell tumor involving the superior rectus muscle: a case report.

IF 3.5 3区 医学 Q2 ONCOLOGY
Frontiers in Oncology Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI:10.3389/fonc.2024.1456960
Pei Wang, Zijian Han, Li Peng, Xiuhong Li, Hongfeng Yuan
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引用次数: 0

Abstract

Objective: The aim of this case report is to assess the clinicopathological characteristics and differential diagnosis of orbital granular cell tumor (GCT).

Methods: Clinical and imaging data of a rare case of orbital GCT involving the superior rectus muscle were collected. Its clinical characteristics, imaging, and histopathological features were observed.

Results: A 36-year-old female patient presented with a 2-year history of left eye proptosis. Magnetic resonance imaging (MRI) enhancement suggested a space-occupying lesion in the left superior rectus muscle region. On T1-weighted and T2-weighted MRI, the tumor was isointense to gray matter and significantly enhanced on the enhanced scan. Microscopic examination revealed that most tumor cells exhibited diffuse growth with unclear boundaries, and some cells were arranged in small nests. The tumor cells were large, with abundant, coarse eosinophilic granules in the cytoplasm. Occasional cells contained larger round eosinophilic droplets in the cytoplasm. Focal areas showed foamy cells, small and central round or oval nuclei with occasional nuclear enlargement and mild atypia, inconspicuous nucleoli, rare mitoses, and low proliferative activity. Immunohistochemistry results were Vimentin (+), S-100 (+), CD68 (+), Ki67 (2%+), Inhibin-a (-), CK (-), SMA (-), and Desmin (-). The pathological examination of a specimen harvested from the mass corresponded to a GCT.

Conclusion: Orbital GCT is rare and should be considered in the differential diagnosis of orbital tumors. It is essential to distinguish it from thyroid-associated ophthalmopathy, inflammatory pseudotumor, and myohemangioma. Definitive diagnosis requires a comprehensive analysis of clinical, histopathological, and immunohistochemical findings. Surgical excision is the primary treatment for orbital GCTs. For patients with incomplete tumor resection, close follow-up is necessary. Proton beam radiation therapy can be considered to prevent recurrence or metastasis if needed.

累及上直肌的眼眶颗粒细胞瘤:病例报告。
目的:本病例报告旨在评估眼眶颗粒细胞瘤(GCT)的临床病理特征和鉴别诊断:本病例报告旨在评估眼眶颗粒细胞瘤(GCT)的临床病理特征和鉴别诊断:方法:收集一例罕见的累及上直肌的眼眶颗粒细胞瘤的临床和影像学资料。方法:收集一例罕见的累及上直肌的眼眶颗粒细胞瘤的临床和影像学资料,观察其临床特征、影像学和组织病理学特征:一名 36 岁的女性患者因左眼突眼就诊 2 年。磁共振成像(MRI)增强显示左上直肌区域有占位性病变。在 T1 加权和 T2 加权磁共振成像中,肿瘤与灰质等密度,增强扫描时肿瘤明显强化。显微镜检查发现,大部分肿瘤细胞呈弥漫性生长,边界不清,部分细胞呈小巢状排列。肿瘤细胞较大,胞浆中有大量粗大的嗜酸性颗粒。偶尔有细胞的胞浆中含有较大的圆形嗜酸性液滴。病灶区域出现泡沫状细胞,核小而集中,呈圆形或椭圆形,偶有核增大和轻度不典型,核小体不明显,有丝分裂少见,增殖活性低。免疫组化结果为波形蛋白(+)、S-100(+)、CD68(+)、Ki67(2%+)、抑制素-a(-)、CK(-)、SMA(-)和 Desmin(-)。从肿块中取出的标本经病理检查显示为 GCT:结论:眼眶GCT非常罕见,应在眼眶肿瘤的鉴别诊断中予以考虑。必须将其与甲状腺相关眼病、炎性假瘤和肌血管瘤区分开来。明确诊断需要对临床、组织病理学和免疫组化结果进行综合分析。手术切除是眼眶 GCT 的主要治疗方法。对于肿瘤切除不彻底的患者,有必要进行密切随访。必要时可考虑质子束放射治疗,以防止复发或转移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Oncology
Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
6.20
自引率
10.60%
发文量
6641
审稿时长
14 weeks
期刊介绍: Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.
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