Clinical Features and Natural Course of Hidradenitis Suppurativa in Turkey: A Multicenter Study.

IF 3 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2024-11-21 DOI:10.1159/000542670

Erkan Alpsoy, Bilge Fettahlıoglu Karaman, Duriye Deniz Demirseren, S Levent Cınar, Nida Kacar, Aylin Türel Ermertcan, Emel Bulbul Baskan, Derya Ucmak, Kifayet Mammadli, Fadime Kılınc, Serkan Yazici, Selami Aykut Temiz, Tugba Özkök Akbulut, Arzu Ataseven, Aysun Şikar Aktürk, Hayriye Sarıcaoğlu, Meltem Türkmen, Fatmagül Gülbaşaran, Burhan Engin, Hatice Kaya Özden, Koray Durmaz, Müge Güler Özden, Hilal Özdemir, Bengü Çevirgen Cemil, Sezgi Sarıkaya Solak, Serap Günes Bilgili, İbrahim Halil Yavuz, Göknur Özaydın Yavuz, Münevver Güven, Algün Polat Ekinci, Tuğba Atcı, Didem Didar Balci, Aylin Oztürk, İlknur Kıvanç Altunay, Ezgi Özkur, Ece Ugurer, Ayse Serap Karadag, Göknur Kalkan, Sevilay Kılıc, Bilgen Erdoğan, Savas Yayli, Leyla Baykal Selçuk, Levent Dönmez, Aslı Bilgic

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引用次数: 0

Abstract

Introduction: The natural history, the progression of a disease process in an individual over time, has not yet been fully elucidated in hidradenitis suppurativa (HS). In this large multicenter study, we aimed to investigate the natural history of HS and its gender differences.

Methods: This cross-sectional study included 827 patients. The chronological order of the clinical manifestations for each patient was recorded retrospectively. Sociodemographic characteristics, triggering factors, clinical, treatment, and prognostic features were also evaluated.

Results: The mean age of disease onset was significantly younger in women than in men (22.42 ± 9.28 vs. 27.06 ± 20.56, p < 0.001) and those with a family history (p < 0.0001). The mean disease duration was 91.17 ± 83.64 months. The most common symptom was purulent discharge (81%). The mean duration of abscess was shorter in women than in men (3.11 ± 2.65 vs. 3.75 ± 3.75, p = 0.01). The axilla was the most common onset area followed by the inguinal and gluteal regions. The disease ran a more severe course in men. Abscess/inflammatory nodule was defined in the last 6 months in 88.6% of the patients; however, the first 5 years of the disease were the most active disease period in 67.5% of the patients. Multivariate analysis revealed being male, older age, family history, involvement of the axillary, inguinal, and perianal regions independently associated with HS severity. While antibiotic use was the most important factor in improving the disease symptoms, stress was the most common aggravating factor. Biological therapy in men, laser epilation and pregnancy in women were significant alleviating factors, whereas weight gain was a more common aggravating factor for women.

Conclusion: HS shows a relentlessly progressive course with inflammatory attacks, but the first years of the disease are the most active period. This study confirms that environmental and hormonal factors may play an important role in the disease course, probably with other endogenous or exogenous factors.

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土耳其化脓性扁桃体炎的临床特征和自然病程：一项多中心研究。

导言：化脓性扁桃体炎（HS）的自然病史，即疾病在个体身上随时间推移而发展的过程，尚未完全阐明。在这项大型多中心研究中，我们旨在调查化脓性扁桃体炎的自然病史及其性别差异：这项横断面研究包括 827 名患者。回顾性记录了每位患者临床表现的时间顺序。研究还评估了社会人口学特征、诱发因素、临床、治疗和预后特征：结果：女性的平均发病年龄明显小于男性（22.42±9.28 vs. 27.06±20.56，p）：HS的病程呈无情的进行性发展，并伴有炎症发作，但疾病的最初几年是最活跃的时期。这项研究证实，环境和激素因素可能在病程中起着重要作用，可能还有其他内源性或外源性因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.