The clinical and microbiological efficacy of a zinc-citrate/hydroxyapatite/potassium-citrate containing toothpaste: a double-blind randomized controlled clinical trial.

IF 3.1 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Uros Josic, Tatjana Maravic, Claudia Mazzitelli, Lorenzo Rinaldi, Carlo D'Alessandro, Diego D'Urso, Gerardo Pellegrino, Annalisa Mazzoni, Lorenzo Breschi
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引用次数: 0

Abstract

Objectives: To evaluate the antibacterial efficacy of two fluoride-containing (1450 ppm F) toothpastes with or without zinc-citrate (ZCT), hydroxyapatite (HAP) and potassium-citrate (KCit); to assess and compare their clinical effects in terms of tooth sensitivity, plaque accumulation and gingivitis, as well as patients' satisfaction.

Materials and methods: Healthy, adult patients were selected and randomly assigned to two groups (n = 50): Experimental: ZCT-, HAP-, KCit- and fluoride-containing toothpaste; Control: fluoride-containing toothpaste. Salivary counts of Streptococcus mutans (S. mutans), plaque and gingival index, as well as clinically diagnosed sensitivity were recorded at baseline, and after 4 weeks. A custom-made questionnaire was used to assess patients' self-reported sensitivity (baseline and after 4 weeks) and overall satisfaction with the tested toothpastes. Data were statistically analyzed (α = 0.05).

Results: After 4 weeks, a statistically significant salivary reduction of S. mutans was observed in both groups (p = 0.001). Furthermore, the percentage of S. mutans decrease was significantly higher in Experimental group (p = 0.014). There were no statistically significant differences between the groups in terms of plaque and gingival index (p > 0.05). After 4 weeks, the self-reported tooth sensitivity was lower in Experimental group (p < 0.001).

Conclusions: Both toothpastes showed good antimicrobial effect after 4 weeks; however, the toothpaste containing ZCT, HAP, KCit and fluoride was found to be more effective in reducing the salivary counts of S. mutans than the product containing fluoride alone.

Clinical relevance: Toothpaste containing ZCT, HAP, KCit and fluoride can be recommended for patients at risk for developing caries and may also be beneficial for individuals experiencing dental sensitivity.

含柠檬酸锌/羟基磷灰石/柠檬酸钾牙膏的临床和微生物疗效:双盲随机对照临床试验。
目的评估含或不含柠檬酸锌(ZCT)、羟基磷灰石(HAP)和柠檬酸钾(KCit)的两种含氟(1450 ppm F)牙膏的抗菌效果;评估和比较它们在牙齿敏感性、牙菌斑堆积和牙龈炎方面的临床效果以及患者的满意度:实验组实验组:含 ZCT、HAP、KCit 和氟化物的牙膏;对照组:含氟牙膏。在基线和 4 周后记录唾液中的变异链球菌(S. mutans)计数、牙菌斑和牙龈指数以及临床诊断的敏感性。定制的问卷用于评估患者自我报告的敏感度(基线和 4 周后)以及对测试牙膏的总体满意度。对数据进行了统计分析(α = 0.05):结果:4 周后,两组唾液中的变异性酵母菌均明显减少(p = 0.001)。此外,实验组的 S. mutans 减少率明显更高(p = 0.014)。在牙菌斑和牙龈指数方面,两组之间没有明显的统计学差异(p > 0.05)。4 周后,实验组的自我报告牙齿敏感度较低(p 结论:实验组的自我报告牙齿敏感度较低,而实验组的自我报告牙齿敏感度较高:4周后,两种牙膏都显示出良好的抗菌效果;但与仅含氟的产品相比,含有 ZCT、HAP、KCit 和氟化物的牙膏能更有效地减少唾液中的变异杆菌数量:临床意义:含 ZCT、HAP、KCit 和氟化物的牙膏可推荐给有患龋齿风险的患者使用,对牙齿敏感的人也可能有益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Oral Investigations
Clinical Oral Investigations 医学-牙科与口腔外科
CiteScore
6.30
自引率
5.90%
发文量
484
审稿时长
3 months
期刊介绍: The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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