Corticospinal excitability and voluntary activation of the quadriceps muscle is not affected by a single session of anodal transcutaneous spinal direct current stimulation in healthy, young adults.

Abstract

The aim of the present study was to determine if anodal transcutaneous spinal direct current stimulation (tsDCS) affects corticospinal excitability (CSE) and voluntary activation (VA) of the quadriceps femoris muscle (QM). This was a double-blind, randomized study in which spine-shoulder anodal tsDCS (active electrode centered over T11-12, 2.5 mA, 20 min) was applied in a seated position. Transcranial magnetic stimulation (TMS) was used to measure motor evoked potentials (MEP) and construct stimulus-response curves in healthy participants (eight females and five males, Experiment 1). VA was measured via the interpolated twitch technique, whereby muscle twitches were evoked using electrical femoral nerve stimulation and TMS (seven females and six males, Experiment 2). Measurements were carried out before, directly, and 30 min after sham and anodal tsDCS (with ≥4 days between sessions). There was no interaction between stimulation × time on stimulus-response curve expressed by slope, stimulus intensity corresponding to 50% of the maximal MEP, and peak-to-peak amplitude of the maximal MEP. Maximal voluntary isometric contraction (MVIC) torque did not change and VA was not affected regardless of the QM torque level (25, 50, or 100% of MVIC). A single, twenty-minute session of spine-shoulder anodal tsDCS did not increase CSE and VA of QM during submaximal and maximal contraction. This suggests that neither excitability to a known input nor responsiveness of motoneurons to submaximal and maximal cortical drive were affected by anodal tsDCS.