Inflammatory Waldenström Macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort.

IF 21 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2024-11-21 DOI:10.1182/blood.2024025738

Pierre-Edouard Debureaux, Stéphanie Poulain, Stephanie Harel, Marie Passet, Marie Templé, Chloe Friedrich, Nathalie Forgeard, Dikelele Elessa, William Plas, Laureen Chat, Gregory Lazarian, Lise Willems, Bruno Royer, Alexis Talbot, Tristan Vaugeois, Floriane Theves, Alexandre Terré, Anne C Brignier, Marion Malphettes, Daphné Krzisch, Laurent Frenzel, Frédéric Davi, Clotilde Bravetti, Florence Nguyen-Khac, Jehan Dupuis, Wendy Cuccuini, Didier Bouscary, Olivier Hermine, Damien Roos-Weil, Olivier Kosmider, Emmanuelle Clappier, Marion Espéli, Karl Balabanian, Bertrand Arnulf

引用次数: 0

Abstract

Inflammation in Waldenström Macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and BTK inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in iWM patients (61% versus 23% in non-inflammatory WM), suggesting a contribution of environmental cells to iWM.

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炎症性瓦尔登斯特伦巨球蛋白血症与克隆性造血有关：一个多中心队列。

瓦尔登斯特伦巨球蛋白血症（iWM）中的炎症可预测免疫化疗和 BTK 抑制剂的疗效，但其起源尚不清楚。在这里，我们揭示了 iWM 患者克隆造血的增加（61%，而非炎症性 WM 患者为 23%），这表明环境细胞对 iWM 有一定的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.