Tellurium Nanoagents with Chiral Shape Efficiently Combat MRSA Infection

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-11-08 DOI:10.1021/acsanm.4c0579010.1021/acsanm.4c05790

Ningning Wang, Bao Wang, Wujuan Li, Leijiao Li*, Xincui Shi, Xiangru Feng, Li Deng* and Wenliang Li*,

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引用次数: 0

Abstract

Infections caused by drug-resistant strains are one of the biggest challenges facing public health. In order to solve this problem, in this paper, tellurium nanoreagents with chiral shapes were prepared by a green method using glutathione as a reducing agent and chiral inducer and fructose as a capping agent and chiral auxiliary. Then, the butterfly-like FTe NPs are bonded with Chlorin e6 to fabricate a nanosystem (FTe-Ce6 NPs) for combating drug-resistant bacterial infection. The proposed FTe-Ce6 not only preserves the high photothermal conversion efficiency of FTe (78.3%) but also improves the stability of Ce6 and promotes the production of ROS. With the aid of NIR irradiation, FTe-Ce6 can eradicate planktonic Escherichia coli and Staphylococcus aureus, especially methicillin-resistant Staphylococcus aureus (MRSA) in vitro. Synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) exhibit broad-spectrum germicidal efficacy. In an in vivo model of MRSA infection, FTe-Ce6 showed high activity in eliminating infection, reducing inflammation, and promoting tissue recovery. This tellurium nanomaterial can be used as an antibiotic-free antimicrobial agent for the treatment of drug-resistant bacterial infections and has potential clinical applications.

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具有手性形状的碲纳米试剂能有效对抗 MRSA 感染

耐药菌株引起的感染是公共卫生面临的最大挑战之一。为了解决这一问题，本文以谷胱甘肽为还原剂和手性诱导剂，果糖为封端剂和手性助剂，采用绿色方法制备了具有手性形状的碲纳米试剂。然后，将蝴蝶状 FTe NPs 与 Chlorin e6 结合，制备出一种纳米系统（FTe-Ce6 NPs），用于抗耐药性细菌感染。所提出的 FTe-Ce6 不仅保留了 FTe 的高光热转换效率（78.3%），还提高了 Ce6 的稳定性并促进了 ROS 的产生。借助近红外照射，FTe-Ce6 可在体外消灭浮游大肠杆菌和金黄色葡萄球菌，尤其是耐甲氧西林金黄色葡萄球菌（MRSA）。协同光热疗法（PTT）和光动力疗法（PDT）具有广谱杀菌功效。在 MRSA 感染的体内模型中，FTe-Ce6 在消除感染、减轻炎症和促进组织恢复方面表现出很高的活性。这种碲纳米材料可用作治疗耐药细菌感染的无抗生素抗菌剂，具有潜在的临床应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.