{"title":"Development of a Scalable Method for the Synthesis of Ethoxy(pentafluoro)cyclotriphosphazene","authors":"Lijun Zhu, Desheng Zhang, Zilong Li, Raoling Ge, Banglong Wan, Qiang Tian, Pengfei Xu","doi":"10.1021/acs.oprd.4c00243","DOIUrl":null,"url":null,"abstract":"Ethoxy(pentafluoro)cyclophosphazene (<b>1</b>) exhibits excellent flame retardancy and various biological activities, and there are numerous synthesis methods available. However, most of these methods have certain problems and shortcomings, such as the use of expensive raw materials and toxic and harmful reagents. To address these issues and uncertainties, we reported the development of a facile and sustainable synthesis method of <b>1</b>, which involves only two concise chemical steps. In this process, the first step contains the reaction of hexachorocyclotriphosphazene (<b>3</b>) with sodium fluoride to yield hexafluorocyclotriphosphazene (<b>2</b>). The second step includes ethoxylation using an ethoxylation reagent, ethanol, and sodium hydroxide as an acid-binding agent to produce <b>1</b> with good quality and an overall yield of 76%. Several advantages are offered by this new synthetic approach, including good reactivity, high yield, low cost, environmental friendliness, and, finally, being industrially viable. The optimized process has been successfully demonstrated on a large scale to support the development of the new energy electric vehicle industry.","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"17 1","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Process Research & Development","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.oprd.4c00243","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Ethoxy(pentafluoro)cyclophosphazene (1) exhibits excellent flame retardancy and various biological activities, and there are numerous synthesis methods available. However, most of these methods have certain problems and shortcomings, such as the use of expensive raw materials and toxic and harmful reagents. To address these issues and uncertainties, we reported the development of a facile and sustainable synthesis method of 1, which involves only two concise chemical steps. In this process, the first step contains the reaction of hexachorocyclotriphosphazene (3) with sodium fluoride to yield hexafluorocyclotriphosphazene (2). The second step includes ethoxylation using an ethoxylation reagent, ethanol, and sodium hydroxide as an acid-binding agent to produce 1 with good quality and an overall yield of 76%. Several advantages are offered by this new synthetic approach, including good reactivity, high yield, low cost, environmental friendliness, and, finally, being industrially viable. The optimized process has been successfully demonstrated on a large scale to support the development of the new energy electric vehicle industry.
期刊介绍:
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools,process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.