Development and Evaluation Essential Oils Nanoemulgel as Human Skin Sanitizer Using Novel Method.

Abstract

Objectives: The increase in epidemic diseases and frequent use of alcoholic disinfectants, despite their side effects, prompt scientists to develop new sterilization products that do not contain alcoholic materials. The aim of this study was to develop, prepare, and evaluate a nanoemulgel skin sanitizer using essential oils (EOs) as active substances.

Materials and methods: A microwave-based technique was used to prepare nanoemulsion. The pseudo-ternary phase plots were constructed to contain three ingredients: EOs, polyoxyethylene (80) sorbitan monooleate, and a propylene glycol mixture (1:0:75) % (w/w) and double distilled. Five samples of nanoemulsion (NE1-NE5) were selected for the characterization and preparation of nanoemulgel (HN1-HN5). Blank gel (HN6) was also prepared to compare the antibacterial activity against HN1-HN5 formulations. Various evaluation processes were achieved for HN1-HN6 formulations. The statistical test was a One-Way analysis of variance at p ≤ 0.05 as significant data.

Results: The characterization process indicates that NE1-NE5 formulations had nanosized droplets, a homogenous distribution, and an acceptable charge. The evaluation process for HN1-HN6 formulations indicates clear, homogenous, with distinctive EO odor and no phase separation, slightly acidic pH, spreadability (128.22 to 124.22 g cm/sec), plastic rheological flow, no skin lesions after application, and conspicuous antimicrobial activity.

Conclusion: Laboratory characterization and evaluation demonstrated the existence of a promising product for sanitizing human skin and could be a successful alternative to alcoholic products based on the growing demand for EO products.