Post-release monitoring pathway for the deployment of gene drive-modified mosquitoes for malaria control in Africa.

IF 2.4 3区 医学 Q3 INFECTIOUS DISEASES
Dorington O Ogoyi, Julia Njagi, Willy Tonui, Brinda Dass, Hector Quemada, Stephanie James
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引用次数: 0

Abstract

Background: Gene drive-modified mosquitoes (GDMMs) have been promoted as one of the innovative technologies that may control and eliminate malaria and other mosquito-borne diseases. Several products are in early stages of development, targeting either population suppression or population modification of the mosquito vector. However, there is no direct experience of conducting risk assessment for environmental releases and subsequent policies regarding conditions for post-release. This study was carried out to gain additional insights on the possible post-release concerns that may arise, as they may inform future risk assessment and planning for deployment.

Methods: This study involved desktop reviews on post release monitoring experiences with previously released biological control products. Stakeholder consultations involving online surveys, and face to face workshop with experts from selected African countries from Eastern, Western, and Southern African regions was then carried out to establish post-release monitoring concerns for GDMMs.

Results: Review of genetic biocontrol technologies showed only limited lessons from post-release monitoring regimes with a focus largely limited to efficacy. For genetically modified organisms general surveillance and case-specific monitoring is expected in some of the regions. A number of post-release monitoring concerns in relation to the protection goals of human and animal health, biodiversity, and water quality were identified.

Conclusion: Based on established- protection goals, several post-release monitoring concerns have been identified. Subject to a rigorous risk assessment process for future GDMMs products, the concerns may then be prioritized for post-release monitoring.

在非洲部署基因驱动改造蚊子以控制疟疾的释放后监测途径。
背景:基因驱动改良蚊子(GDMMs)已被推广为可能控制和消除疟疾及其他蚊媒疾病的创新技术之一。有几种产品正处于早期开发阶段,其目标是抑制蚊媒的数量或改变蚊媒的数量。然而,目前还没有对环境释放进行风险评估的直接经验,也没有关于释放后条件的后续政策。开展这项研究是为了进一步了解释放后可能出现的问题,以便为今后的风险评估和部署规划提供信息:这项研究包括对以前释放的生物控制产品的释放后监测经验进行桌面审查。然后,与利益相关者进行磋商,包括在线调查,以及与来自非洲东部、西部和南部地区选定非洲国家的专家举行面对面的研讨会,以确定 GDMM 释放后监测方面的问题:结果:对基因生物控制技术的审查表明,释放后监测制度的经验教训有限,重点主要局限于功效。对于转基因生物,预计某些地区会进行一般性监测和针对具体案例的监测。结论:根据既定的保护目标,确定了若干释放后监测问题。在对未来的 GDMMs 产品进行严格的风险评估后,这些问题可能会被列为释放后监测的优先事项。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Malaria Journal
Malaria Journal 医学-寄生虫学
CiteScore
5.10
自引率
23.30%
发文量
334
审稿时长
2-4 weeks
期刊介绍: Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field.
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