Causes and clinical characteristics of women with primary amenorrhea and ovarian or gonadal disorders at a quaternary hospital.

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-11-21 DOI:10.1111/jog.16165

Krantarat Peeyananjarassri, Satit Klangsin, Apisada Chumkam, Saranya Wattanakumtornkul, Kriengsak Dhanaworavibul, Chainarong Choksuchat, Chatpavit Getpook, Phawat Matemanosak, Chariyawan Charalsawadi, Worathai Maisrikhaww

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引用次数: 0

Abstract

Aim: To evaluate the causes and clinical characteristics of primary amenorrhea and ovarian or gonadal disorders in women.

Methods: The medical records of all women evaluated for primary amenorrhea between January 2002 and December 2023 were retrospectively reviewed. Women with missing data were excluded from the study. Disorders of the ovary or gonads (hypergonadotropic hypogonadism) were defined as increased serum follicle-stimulating hormone (FSH) levels (>40 mIU/mL).

Results: Over a 21-year period, after excluding 1 woman with incomplete data, the study included 87 women who met the inclusion criteria. The median age at presentation was 18 years (interquartile range [IQR], 17-20). The median estradiol level was 5 pg/mL (IQR 5-10.4), and the median FSH level was 80 mIU/mL (IQR 63.1-94.9). The most common cause of primary amenorrhea was Turner syndrome (TS), followed by 46,XX and 46,XY gonadal dysgenesis. The median height was 147 cm (IQR, 140-158.7), and 50 women (57.5%) had karyotypic abnormalities, with TS being the most common abnormality.

Conclusion: TS was identified as the most common cause of primary amenorrhea with ovarian or gonadal disorders.

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一家四级医院中患有原发性闭经和卵巢或性腺疾病的妇女的病因和临床特征。

目的：评估女性原发性闭经和卵巢或性腺疾病的原因和临床特征：方法：回顾性审查 2002 年 1 月至 2023 年 12 月期间所有接受原发性闭经评估的女性的病历。研究排除了数据缺失的女性。卵巢或性腺疾病（促性腺功能减退症）定义为血清卵泡刺激素（FSH）水平升高（>40 mIU/mL）：在 21 年的时间里，在排除了 1 名数据不完整的女性后，该研究共纳入了 87 名符合纳入标准的女性。发病时的中位年龄为 18 岁（四分位数间距 [IQR]，17-20 岁）。雌二醇水平中位数为 5 pg/mL（IQR 5-10.4），FSH 水平中位数为 80 mIU/mL（IQR 63.1-94.9）。原发性闭经最常见的原因是特纳综合征（TS），其次是 46,XX 和 46,XY 性腺发育不良。身高中位数为 147 厘米（IQR，140-158.7），50 名女性（57.5%）有核型异常，其中 TS 是最常见的异常：结论：TS 是原发性闭经伴有卵巢或性腺疾病的最常见原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.