Impact of astaxanthin supplementation on markers of cardiometabolic health and tactical performance among firefighters.

IF 4.5 2区 医学 Q1 NUTRITION & DIETETICS
Drew E Gonzalez, Broderick L Dickerson, Sarah E Johnson, Kathryn E Woodruff, Megan Leonard, Choongsung Yoo, Joungbo Ko, Dante Xing, Victoria Martinez, Jacob Kendra, Landry Estes, Ryan J Sowinski, Chris J Rasmussen, Steven E Martin, Richard B Kreider
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引用次数: 0

Abstract

Rationale: Firefighters are at risk for cardiovascular disease due to occupational-related inflammation, oxidative stress, and lifestyle practices. Astaxanthin (AX) possesses anti-inflammatory/antioxidant and purported ergogenic properties. This study examined the impact of supplementing the diet with 12 mg/d AX for four weeks on markers of inflammation, oxidative stress, cardiometabolic health, exercise capacity, and occupation-related performance in career firefighters.

Methods: In a randomized, double-blinded, placebo-controlled, crossover fashion, 15 male career firefighters (34.5 ± 7.4 years; 177.7 ± 7.0 cm; 95.6 ± 12.0 kg; 30.1 ± 2.9 kg/m2; 11.03 ± 6.85 years of service) ingested 12 mg/d of AX (AstaReal®, AstaReal AB, Nacka, SWE) or placebo (PLA) for four weeks while following a standardized resistance training program. After each treatment, testing sessions were completed to assess inflammatory markers, oxidative stress markers, cardiopulmonary exercise capacity, and performance to a fire ground test (FGT) consisting of nine fire suppressive activities. Data were analyzed using general linear model (GLM) analysis with repeated measures. Clinical significance was assessed via mean changes from baseline with 95% confidence intervals.

Results: Analysis of mean percent changes from baseline revealed that AX supplementation lessened the inflammatory response to to performing an incremental maximal exercise test and attenuated increases in interleukin-1β, cortisol, and uric acid in response to performing fire suppressive activities compared to when they ingested PLA. However, most of these effects were within groups rather than between groups. Additionally, there was evidence that AX ingestion increased the ventilatory anaerobic threshold. Four weeks of AX supplementation did not significantly affect fasting markers of oxidative stress, blood lipids, performance during the FGT, general clinical chemistry panels, or self-reported side effects.

Conclusions: Results provide some evidence that AX supplementation may help mediate occupation-related inflammation in response to high-intensity, short-duration exercise in firefighters. More research is warranted to determine if long-term supplementation can improve cardiometabolic risk in this population.

Clinical trial registration: ISRCTN10901752.

补充虾青素对消防员心脏代谢健康指标和战术表现的影响。
理由:由于与职业相关的炎症、氧化应激和生活习惯,消防员面临罹患心血管疾病的风险。虾青素(AX)具有抗炎/抗氧化作用,据称还具有增强体质的作用。本研究考察了在饮食中补充 12 毫克/天的 AX,并持续四周对职业消防员的炎症指标、氧化应激、心脏代谢健康、运动能力和职业相关表现的影响:采用随机、双盲、安慰剂对照、交叉的方法,15 名男性职业消防员(34.5 ± 7.4 岁;177.7 ± 7.0 厘米;95.6 ± 12.0 千克;30.1 ± 2.9 千克/平方米;11.03 ± 6.85 服役年限)每天摄入 12 毫克 AX(AstaReal®,AstaReal AB,Nacka,SWE)或安慰剂(PLA),为期四周,同时进行标准化阻力训练。每次治疗后,都要进行测试,以评估炎症指标、氧化应激指标、心肺运动能力以及由九种灭火活动组成的火场测试(FGT)成绩。数据采用一般线性模型(GLM)分析和重复测量法进行分析。临床意义通过与基线相比的平均变化及 95% 的置信区间进行评估:与摄入聚乳酸时相比,分析与基线相比的平均百分比变化显示,补充 AX 可减轻进行增量最大运动测试时的炎症反应,并可减轻进行火力压制活动时白细胞介素-1β、皮质醇和尿酸的增加。不过,这些影响大多发生在组内而非组间。此外,有证据表明,摄入 AX 提高了通气无氧阈值。为期四周的 AX 补充剂不会对空腹氧化应激指标、血脂、FGT 期间的表现、一般临床生化指标或自我报告的副作用产生明显影响:结论:研究结果提供了一些证据,表明补充 AX 可能有助于调解消防员在进行高强度、短时间运动时与职业相关的炎症反应。临床试验注册:临床试验注册:ISRCTN10901752。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of the International Society of Sports Nutrition
Journal of the International Society of Sports Nutrition NUTRITION & DIETETICS-SPORT SCIENCES
CiteScore
8.80
自引率
3.90%
发文量
34
审稿时长
6-12 weeks
期刊介绍: Journal of the International Society of Sports Nutrition (JISSN) focuses on the acute and chronic effects of sports nutrition and supplementation strategies on body composition, physical performance and metabolism. JISSN is aimed at researchers and sport enthusiasts focused on delivering knowledge on exercise and nutrition on health, disease, rehabilitation, training, and performance. The journal provides a platform on which readers can determine nutritional strategies that may enhance exercise and/or training adaptations leading to improved health and performance.
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