Receptor-Interacting Protein Kinase 3 as a Serological Biomarker in Relation to Disease Severity and Delirium After Acute Pancreatitis: A Prospective Cohort Study.

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S488540
Xiaorong Ye, Bingzhen Li, Fang Xu, Debiao Pan, Jing Wu
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引用次数: 0

Abstract

Objective: Delirium is a common complication of acute pancreatitis. Receptor-interacting protein kinase 3 (RIP3) is an activator of programmed cell necrosis. This study aimed to determine its ability to predict delirium after acute pancreatitis.

Methods: In total, 297 patients with acute pancreatitis were prospectively enrolled in this study. Patients were divided into two subgroups (study and validation groups: 197 and 100 cases, respectively). Serum RIP3 levels were measured in all patients and in 100 healthy controls. Acute Physiology and Chronic Health Evaluation (APACHE) II, Ranson, and sequential organ failure assessment (SOFA) scores were used for the severity assessment. In-hospital delirium was observed as an outcome variable. Multifactorial analyses were performed to discern severity correlations and outcome associations.

Results: Serum RIP3 levels were significantly higher in the patients than in the controls. Serum RIP3 levels had linear relationships under the restricted cubic spline and were independently correlated with APACHE II, Ranson, and SOFA scores. Serum RIP3 levels were linearly correlated with the likelihood of developing in-hospital delirium and exhibited a strong discrimination efficiency under the receiver operating characteristic curve. Serum RIP3 levels, coupled with APACHE II scores, Ranson scores, and SOFA scores, were the four independent predictors of in-hospital delirium. No interactions were revealed regarding its relevance to sex, age, or body mass index in subgroup analysis. These were integrated to form a model graphically represented by a nomogram that showed effective stability, clinical fit, and predictive ability for in-hospital delirium. The model was verified in the validation group.

Conclusion: An incremental trend in serum RIP3 levels was notable after acute pancreatitis. Serum RIP3 levels are independently related to illness severity and occurrence of in-hospital delirium, indicating that serum RIP3 may be a potential biomarker of acute pancreatitis.

受体相互作用蛋白激酶 3 作为血清生物标记物与急性胰腺炎后疾病严重程度和谵妄的关系:一项前瞻性队列研究
目的:谵妄是急性胰腺炎的常见并发症:谵妄是急性胰腺炎的常见并发症。受体相互作用蛋白激酶 3 (RIP3) 是程序性细胞坏死的激活剂。本研究旨在确定其预测急性胰腺炎后谵妄的能力:本研究共招募了 297 名急性胰腺炎患者。患者被分为两个亚组(研究组和验证组:分别为 197 例和 100 例)。对所有患者和 100 名健康对照者的血清 RIP3 水平进行了测定。严重程度评估采用急性生理学和慢性健康评估(APACHE)II、Ranson 和序贯器官衰竭评估(SOFA)评分。院内谵妄作为一个结果变量进行观察。进行多因素分析以确定严重程度相关性和结果关联性:结果:患者血清 RIP3 水平明显高于对照组。血清 RIP3 水平在受限立方样条线下呈线性关系,并与 APACHE II、Ranson 和 SOFA 评分独立相关。血清 RIP3 水平与发生院内谵妄的可能性呈线性相关,在接收者操作特征曲线下表现出很强的区分效率。血清 RIP3 水平与 APACHE II 评分、Ranson 评分和 SOFA 评分是院内谵妄的四个独立预测因子。在亚组分析中,未发现其与性别、年龄或体重指数的相互作用。这些因素整合后形成了一个以提名图表示的模型,该模型显示出有效的稳定性、临床拟合度和对院内谵妄的预测能力。该模型在验证组中得到了验证:结论:急性胰腺炎发生后,血清 RIP3 水平呈显著上升趋势。血清RIP3水平与病情严重程度和院内谵妄的发生独立相关,表明血清RIP3可能是急性胰腺炎的潜在生物标志物。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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