Impact of Nutritional Status on Chemotherapy Related Digestive Toxicity in Women With Breast Cancer.

IF 2.3 Q3 NUTRITION & DIETETICS

Nutrition and Metabolic Insights Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI:10.1177/11786388241297142

Berriche Olfa, Mohsen Salma, Ben Othman Rym, Ben Mansour Hajer, Khiari Houyem, Jamoussi Henda, Mezlini Amel

{"title":"Impact of Nutritional Status on Chemotherapy Related Digestive Toxicity in Women With Breast Cancer.","authors":"Berriche Olfa, Mohsen Salma, Ben Othman Rym, Ben Mansour Hajer, Khiari Houyem, Jamoussi Henda, Mezlini Amel","doi":"10.1177/11786388241297142","DOIUrl":null,"url":null,"abstract":"Introduction: Any alteration in nutritional status can compromise the progression of breast cancer, as well as the tolerance and efficacy of chemotherapy. The aims of our study were to assess the nutritional status of breast cancer patients treated with chemotherapy and to identify nutritional factors that may exacerbate chemo-induced digestive toxicity.Methods: This descriptive cross-sectional study was conducted within the medical oncology department of the National Institute of Salah Azaiez. A Mediterranean Diet Score (MDS) was used to evaluate the level of adherence to the Mediterranean Diet. Nutritional status was assessed using 2 methods; body composition evaluation utilising the TANITA BC 601 impedance metre and High authority of health (HAS) criteria of malnutrition. Digestive effects were assessed with World Health Organization (WHO) grades ranging from 0 to 4. High grades 3 and 4 signified toxic grades.Results: We enrolled 107 adult women diagnosed with breast cancer undergoing the same chemotherapy protocol. The participants had an average age of 52.56 ± 9.75 years and an average BMI of 29.85 ± 5.72 kg/m2 with 78.5% classified as overweight. Malnutrition was observed in 41% of patients, while sarcopenia was present in 12%. Chemotherapy-related adverse effects were predominantly constipation (80%), diarrhea (73%), nausea (70%) and vomiting (63.4%) with one-third experiencing high-grade toxicity. Strong adherence to Mediterranean Diet was observed in 48.6% of cases and higher MDS scores were inversely correlated with the severity of nausea (P = .01) and constipation (P = .02). Malnutrition was significantly associated with all digestive toxicities except with constipation. Sarcopenia was associated only with vomiting (P = .005).Conclusion: There is a relationship between nutritional status and digestive toxicity, justifying early nutritional treatment to improve the tolerance and efficacy of chemotherapy.","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"17 ","pages":"11786388241297142"},"PeriodicalIF":2.3000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577464/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition and Metabolic Insights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11786388241297142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Any alteration in nutritional status can compromise the progression of breast cancer, as well as the tolerance and efficacy of chemotherapy. The aims of our study were to assess the nutritional status of breast cancer patients treated with chemotherapy and to identify nutritional factors that may exacerbate chemo-induced digestive toxicity.

Methods: This descriptive cross-sectional study was conducted within the medical oncology department of the National Institute of Salah Azaiez. A Mediterranean Diet Score (MDS) was used to evaluate the level of adherence to the Mediterranean Diet. Nutritional status was assessed using 2 methods; body composition evaluation utilising the TANITA BC 601 impedance metre and High authority of health (HAS) criteria of malnutrition. Digestive effects were assessed with World Health Organization (WHO) grades ranging from 0 to 4. High grades 3 and 4 signified toxic grades.

Results: We enrolled 107 adult women diagnosed with breast cancer undergoing the same chemotherapy protocol. The participants had an average age of 52.56 ± 9.75 years and an average BMI of 29.85 ± 5.72 kg/m² with 78.5% classified as overweight. Malnutrition was observed in 41% of patients, while sarcopenia was present in 12%. Chemotherapy-related adverse effects were predominantly constipation (80%), diarrhea (73%), nausea (70%) and vomiting (63.4%) with one-third experiencing high-grade toxicity. Strong adherence to Mediterranean Diet was observed in 48.6% of cases and higher MDS scores were inversely correlated with the severity of nausea (P = .01) and constipation (P = .02). Malnutrition was significantly associated with all digestive toxicities except with constipation. Sarcopenia was associated only with vomiting (P = .005).

Conclusion: There is a relationship between nutritional status and digestive toxicity, justifying early nutritional treatment to improve the tolerance and efficacy of chemotherapy.

查看原文本刊更多论文

营养状况对乳腺癌妇女化疗相关消化道毒性的影响

简介任何营养状况的改变都会影响乳腺癌的进展以及化疗的耐受性和疗效。我们的研究旨在评估接受化疗的乳腺癌患者的营养状况，并找出可能加剧化疗引起的消化道毒性的营养因素：这项描述性横断面研究在萨拉赫-阿扎埃兹国家研究所肿瘤内科进行。地中海饮食评分（MDS）用于评估地中海饮食的坚持程度。营养状况采用两种方法进行评估：利用 TANITA BC 601 阻抗仪进行身体成分评估，以及采用卫生部营养不良标准（HAS）进行评估。消化系统的影响用世界卫生组织（WHO）0-4级标准进行评估，3级和4级为中毒级：我们招募了 107 名被诊断患有乳腺癌并接受相同化疗方案的成年女性。参与者的平均年龄为（52.56 ± 9.75）岁，平均体重指数（BMI）为（29.85 ± 5.72）kg/m2，78.5%属于超重。41%的患者出现营养不良，12%的患者出现肌肉疏松症。与化疗相关的不良反应主要是便秘（80%）、腹泻（73%）、恶心（70%）和呕吐（63.4%），其中三分之一的患者出现高度毒性。48.6%的病例坚持地中海饮食，较高的MDS评分与恶心（P = .01）和便秘（P = .02）的严重程度成反比。除便秘外，营养不良与所有消化系统毒性反应均有明显相关性。营养不良仅与呕吐有关（P = .005）：结论：营养状况与消化系统毒性之间存在一定关系，因此应尽早进行营养治疗，以提高化疗的耐受性和疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.