Association of erectile dysfunction and peripheral arterial disease in NHANES 2001-2004: a cross-sectional study.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI:10.3389/fendo.2024.1439609

Ganggang Wang, Caifang Ni

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引用次数: 0

Abstract

Objective: To evaluate the association between Erectile dysfunction (ED) and peripheral arterial disease (PAD) in adult American males using a large database.

Methods: The relationship between ED and PAD prevalence among participants in the 2001-2004 National Health and Nutrition Examination Survey (NHANES) database was assessed using a series of statistical analyses. ED was evaluated based on a single-item measure of self-reported erection problems from the Massachusetts Male Aging Study. PAD was defined as ankle-brachial index (ABI) < 0.9 in at least one leg. Multifactorial logistic regression models were used to investigate the association between ED and PAD.

Results: A total of 2394 participants were enrolled, of whom 905 individuals (37.8%) were diagnosed with ED. After adjusting for confounding variables, the association between ED and PAD remained positive, with an odds ratio of 2.05 (95% confidence interval 1.24-3.39). Subgroup analysis revealed that the relationship between ED and PAD was significant in patients aged >50 years old, without hypertension, without diabetes, without cardiovascular disease, without high cholesterol, former smokers, low physical activity levels, and a body mass index of 25-30 (P < 0.05). In addition, all subgroups analyzed were evaluated for any potential interaction, and no statistically significant association was discovered.

Conclusions: In a sample of US adults aged ≥40, this cross-sectional study found that ED is related to a higher occurrence of PAD. ED may be an independent predictor of PAD, and thus it should be considered in the treatment of patients with ED.

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2001-2004 年国家健康调查（NHANES）中勃起功能障碍与外周动脉疾病的关系：一项横断面研究。

目的利用大型数据库评估美国成年男性勃起功能障碍（ED）与外周动脉疾病（PAD）之间的关系：方法：通过一系列统计分析，评估 2001-2004 年美国国家健康与营养调查（NHANES）数据库参与者中勃起功能障碍与 PAD 患病率之间的关系。ED是根据马萨诸塞州男性衰老研究（Massachusetts Male Aging Study）中自我报告的勃起问题的单项测量进行评估的。PAD定义为至少一条腿的踝肱指数（ABI）<0.9。多因素逻辑回归模型用于研究 ED 与 PAD 之间的关联：共有 2394 人参加了研究，其中 905 人（37.8%）被诊断为 ED。在对混杂变量进行调整后，ED 与 PAD 之间的关系仍为正相关，几率比为 2.05（95% 置信区间为 1.24-3.39）。亚组分析显示，在年龄大于 50 岁、无高血压、无糖尿病、无心血管疾病、无高胆固醇、曾经吸烟、体力活动水平低以及体重指数在 25-30 之间的患者中，ED 与 PAD 之间的关系显著（P < 0.05）。此外，还对所有分析的亚组进行了潜在交互作用的评估，结果未发现有统计学意义的关联：这项横断面研究发现，在年龄≥40岁的美国成年人样本中，ED与PAD的高发病率有关。ED 可能是 PAD 的一个独立预测因素，因此在治疗 ED 患者时应考虑到这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.