Recent Progress in Steroid C(sp3)-H Functionalization.

IF 7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Agnieszka Wojtkielewicz, Adam D Majewski, Zenon Łotowski
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引用次数: 0

Abstract

Selective C-H functionalization methods could provide a valuable tool for synthesizing different steroid derivatives, which is essential not only in contexts of developing novel synthetic methodology but also as a direct way for gathering the analogues needed for studying the structure-activity relationships and obtaining biologically active compounds. The review discusses recent examples of steroid C-H functionalization to various C-X derivatives (C-O, C-C, C-N, C-S, and C-halogen) using available methods emphasizing their scope and limitations.

类固醇 C(sp3)-H 官能化的最新进展。
选择性 C-H 功能化方法可以为合成不同的类固醇衍生物提供有价值的工具,这不仅对开发新的合成方法至关重要,而且也是收集研究结构-活性关系和获得生物活性化合物所需的类似物的直接途径。本综述讨论了利用现有方法将类固醇 C-H 功能化为各种 C-X 衍生物(C-O、C-C、C-N、C-S 和 C-卤素)的最新实例,强调了这些方法的范围和局限性。
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来源期刊
Chemical record
Chemical record 化学-化学综合
CiteScore
11.00
自引率
3.00%
发文量
188
审稿时长
>12 weeks
期刊介绍: The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.
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