Diffusion-weighted imaging based on intravoxel incoherent motion: correlation with molecular prognostic factors and subtypes in breast cancer.

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Dan Yang, Yike Ren, Guanying Wang, Chunhong Wang
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引用次数: 0

Abstract

Background: Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), which indicates biological tissue attributes, may be applied to accurately assess breast tumors.

Purpose: To analyze the IVIM parameters of different molecular prognostic factors and subtypes to find out whether there are any connections.

Material and methods: A total of 181 patients enrolled in this retrospective study had preoperative magnetic resonance imaging (MRI) examinations, and pathologies were verified as breast cancers. Regions of interest were placed at all slices of the parameter maps (D, tissue diffusivity; ADC, apparent diffusion coefficient; f, perfusion fraction; and D*, pseudo-diffusivity maps) of IVIM and generated parameter values to be used for comparative analysis among molecular prognostic factors and subtypes.

Results: D and ADC were greater in estrogen receptor (ER)-negative, human epidermal growth factor receptor 2 (HER2)-positive, and Ki67-low expression groups (all P values < 0.05). The progesterone receptor (PR)-negative group had a higher D value (P < 0.05). f was larger in the lymph node metastasis-negative group and the PR-positive group (P = 0.012 and 0.046, respectively). Among breast cancer subtypes, D and ADC were different between the HER2-overexpression and the Luminal B (HER2-negative) subtypes (P = 0.019 and 0.028, respectively). The difference in D between the luminal and non-luminal subtypes was statistically significant (P = 0.008). The triple-negative subtype significantly differs from the other subtypes in D* and f (P = 0.012 and 0.016, respectively).

Conclusion: IVIM-related metrics exhibited relationships with breast cancer molecular prognosis factors and subtypes.

基于体内非相干运动的弥散加权成像:与乳腺癌分子预后因素和亚型的相关性。
背景:目的:分析不同分子预后因素和亚型的IVIM参数,找出其中是否存在关联:这项回顾性研究共对181名患者进行了术前磁共振成像(MRI)检查,病理证实为乳腺癌。在 IVIM 参数图(D,组织弥散度;ADC,表观弥散系数;f,灌注分数;D*,假弥散度图)的所有切片上放置感兴趣区,并生成参数值,用于分子预后因素和亚型之间的比较分析:雌激素受体(ER)阴性组、人表皮生长因子受体 2(HER2)阳性组和 Ki67 低表达组的 D 和 ADC 更大(所有 P 值分别为 0.012 和 0.046)。在乳腺癌亚型中,HER2-表达阳性亚型和Luminal B(HER2-阴性)亚型的D和ADC不同(P = 0.019和0.028)。管腔亚型与非管腔亚型之间的 D 差异具有统计学意义(P = 0.008)。三阴性亚型在 D* 和 f 方面与其他亚型有显著差异(P = 0.012 和 0.016):结论:IVIM相关指标与乳腺癌分子预后因素和亚型有一定关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta radiologica
Acta radiologica 医学-核医学
CiteScore
2.70
自引率
0.00%
发文量
170
审稿时长
3-8 weeks
期刊介绍: Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.
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